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Should men whose female partners have cervical high grade intraepithelial lesion (HSIL) be screened?
Eur J Obstet Gynecol Reprod Biol
March 2025
CerbaPath, 30 Bd de Vaugirard, Paris 75015, France.
Objective: The subject of screening for genital HPV lesions in the male partner of women with cervical high-grade squamous intraepithelial lesions (HSIL) remains a topic of discussion. The present study evaluated the prevalence of penile high-grade squamous intraepithelial lesion (HSIL) clinical lesions in 196 men whose female partners had been diagnosed with cervical low-grade and high-grade intraepithelial lesions (LSIL, HSIL) in Ile-de-France.
Methods: In cases involving couples where the female partner had been diagnosed with a cervical LSIL or HSIL lesion, the male partner underwent examination using the peniscopy method.
Novel Role Of DSNB in Staging of Primary Urethral Cancer: New Standard?
Int Braz J Urol
March 2025
Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
We describe the novel use of dynamic sentinel node biopsy (DSNB) in five patients with primary urethral squamous cell carcinoma (U-SCC) and no evidence of inguinal node disease across two centers in North America and Europe between 03/2021 and 06/2024. Each of these referral centers sees over 75 cases of penile cancer per year and approximately 10 cases of U-SCC per year. Patients underwent DSNB concomitant to surgical resection of the primary tumor (n=3), or in a deferred manner (n=2), six weeks after primary surgery.
View Article and Find Full Text PDFImmunotherapy in the Management of Penile Cancer-A Systematic Review.
Cancers (Basel)
March 2025
Divison of Oncology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Penile cancer, though a rare malignancy, presents a significant challenge in the domain of male genitourinary oncology, particularly due to its limited treatment options and due to the profound physical and psychological impact on patients [...
View Article and Find Full Text PDFEfficacy and safety of immune checkpoint inhibitors in metastatic penile squamous cell carcinoma: a retrospective multicenter analysis.
Exp Hematol Oncol
March 2025
The University of Kansas Cancer Center, 2650 Shawnee Mission Pkwy, Westwood, KS, 66205, United States of America.
Penile squamous cell carcinoma (PSCC) is a rare malignancy, and first-line therapy typically involves cisplatin-based chemotherapy. However, these regimens are often unsuitable for patients with poor performance status or advanced age due to their toxicity. This retrospective, multicenter study evaluated patients with metastatic PSCC who received immune checkpoint inhibitor (ICI) therapy between 2017 and 2024.
View Article and Find Full Text PDFA patient with penile metastasis secondary to small cell lung cancer successfully treated with PD-1 inhibitors and chemotherapy: a case report and literature review.
Front Oncol
February 2025
Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Background: Penile metastasis is an uncommon condition, with most primary malignancies originating in the abdominal cavity and pelvis. There have been very few reported cases originating from lung cancer, most of squamous cell carcinoma without small cell lung cancer.
Methods: We presented a case of penile metastasis secondary to small cell lung cancer, along with a review of relevant literature from the CNKI database.
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