AI Article Synopsis
- A meta-analysis of randomized controlled trials (RCTs) examined the effectiveness and safety of bronchoscopic lung volume reduction (BLVR) in patients with severe emphysema compared to conventional therapy.
- The analysis included 3 RCTs for endobronchial coils, 6 for endobronchial valves (EBV), and 2 for intrabronchial valves (IBV), with both coils and EBV showing significant improvements in lung function, exercise capacity, and quality of life.
- The results indicate that while coils and EBV are beneficial, IBV did not outperform conventional therapy and more research is needed, especially for coils in patients with homogeneous emphysema.
Article Abstract
Background: Increasing randomized controlled trials (RCTs) indicate that bronchoscopic lung volume reduction (BLVR) is effective for severe emphysema. In this meta-analysis, we investigated the efficacy and safety of BLVR in patients with severe emphysema.
Methods: PubMed, Embase and the Cochrane Library and reference lists of related articles were searched, and RCTs that evaluated BLVR therapy VS conventional therapy were included. Meta-analysis was performed only when included RCTs ≥ 2 trials.
Results: In total, 3 RCTs for endobronchial coils, 6 RCTs for endobronchial valves (EBV) and 2 RCTs for intrabronchial valves (IBV) were included. Compared with conventional therapy, endobronchial coils showed better response in minimal clinically important difference (MCID) for forced expiratory volume in 1s (FEV1) (RR = 2.37, 95% CI = 1.61 - 3.48, < 0.0001), for 6-min walk test (6MWT) (RR = 2.05, 95% CI = 1.18 - 3.53, p = 0.01), and for St. George's Respiratory Questionnaire (SGRQ) (RR = 2.32, 95% CI = 1.77 - 3.03, p < 0.00001). EBV therapy also reached clinically significant improvement in FEV1 (RR = 2.96, 95% CI = 1.49 - 5.87, = 0.002), in 6MWT (RR = 2.90, 95% CI = 1.24 - 6.79, p = 0.01), and in SGRQ (RR = 1.53, 95% CI = 1.22 - 1.92, p = 0.0002). Both coils and EBV treatment achieved statistically significant absolute change in FEV1, 6MWT, and SGRQ from baseline, also accompanied by serious adverse effects. Furthermore, subgroup analysis showed there was no difference between homogeneous and heterogeneous emphysema in coils group. However, IBV group failed to show superior to conventional group.
Conclusions: Current meta-analysis indicates that coils or EBV treatment could significantly improve pulmonary function, exercise capacity, and quality of life compared with conventional therapy. Coils treatment could be applied in homogeneous emphysema, but further trials are needed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652834 | PMC |
| http://dx.doi.org/10.18632/oncotarget.19352 | DOI Listing |
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