- to assess the risk of coronary disease in patients with asymptomatic ischemia. The work was based on the results of 185 patients' investigation, aged 35-55, among them 159 men and 26 women. All of them underwent selective coronarography. The patients were distributed according to the coronarography data - the first group consisted of individuals who had any coronary stenosis. The second group consisted of patients with intact coronaries. Statistical analysis was performed using the program packet SPSS v. 22. Our investigation showed that patients' median age did not credibly differ in the group of stenosis - 47.18 ± 5.14 and the group of intact coronaries 46.14 ± 5.06. More than 50% of any coronary stenosis shows convincing positive correlation with LV moderate dilatation - r=0.531; p=0.000 and 30 to 50% stenosis - r=0.531; p=0.000. Dyslipidemia, EF<53.8 p=0.000, obesity, ventricular extrasystoles, ST ↓ or ST ↑, positive treadmill test, low tolerance to treadmill test, arterial hypertension, cardiac insufficiency (heart failure), occupational dust, occupational hazards, stressful job, heavy physical load or professional sport; ischemic disease in 1st degree relatives, hereditary heart diseases, frequent alcohol consumption, urban living place, diabetes mellitus, smoking, male gender show convincingly positive correlation with coronary artery stenosis. Negative correlation is shown by the nondiagnostic treadmill test and the sinus rhythm. In patients with silent ischemia, the coronary disease predictors are: left ventricular moderate dilatation, male gender, dyslipidemia, arterial hypertension, smoking, positive treadmill test, ischemic disease in 1st degree relatives, low tolerance to treadmill test.
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Medicine (Baltimore)
January 2025
Zhengzhou Central Hospital Affiliated to Zhengzhou University, Henan, China.
Inflammatory responses and lipid metabolism disorders are key components in the development of coronary artery disease and contribute to no-reflow after coronary intervention. This study aimed to investigate the association between the neutrophil to high-density lipoprotein ratio (NHR) and no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PPCI). This study enrolled 288 patients with STEMI from September 1st, 2022 to February 29th, 2024, in the Zhengzhou Central Hospital Affiliated to Zhengzhou University.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Chronic coronary artery disease (CAD) remains a significant global healthcare burden. Current risk assessment methods have notable limitations in early detection and risk stratification. Hence, there is an urgent need for innovative biomarkers that facilitate the premature CAD diagnosis, ultimately leading to reduction in associated morbidity and mortality rates.
View Article and Find Full Text PDFPLoS One
January 2025
NIE-Indian Council of Medical Research-National Institute of Epidemiology, Chennai, India.
Background: Judicious utilisation of tertiary care facilities through appropriate risk stratification assumes priority, in a raging pandemic, of the nature of delta variant-predominated second wave of COVID-19 pandemic in India. Prioritisation of tertiary care, through a scientifically validated risk score, would maximise recovery without compromising individual safety, but importantly without straining the health system.
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PLoS One
January 2025
Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, the association between glyphosate and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims to explore the effect of glyphosate exposure on ASCVD.
View Article and Find Full Text PDFJ Infect Dis
January 2025
School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Background: Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, the relationships between the gut microbiome, inflammation and HIV remain unclear.
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