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Development of precision medicine approaches to advance clinical trials for autism and social behavior: A research imperative.
Proc Natl Acad Sci U S A
January 2025
Clinic for Autism and Neurodevelopmental research, Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.
Psychogenetic Features of Heredity and Pathology.
J Nerv Ment Dis
January 2025
Department of Psychology and Pedagogy, Kyiv International University, Kyiv, Ukraine.
The purpose of this study is to provide an in-depth examination of the complex aspects of hereditary and pathological conditions arising based on psychogenetic factors, in particular, the disclosure of elements that determine the causes of their appearance. The following methods were used in the study: analytical, typological approaches, and generalization. It was found that genetic inheritance plays a significant role in the occurrence of autism spectrum disorders, bipolar disorder, schizophrenia, and other pathologies.
View Article and Find Full Text PDFProbing the Neurodynamic Mechanisms of Cognitive Flexibility in Depressed Individuals with Autism Spectrum Disorder.
J Child Adolesc Psychopharmacol
January 2025
Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Autism spectrum disorder (ASD) is characterized by deficits in social behavior and executive function (EF), particularly in cognitive flexibility. Whether transcranial magnetic stimulation (TMS) can improve cognitive outcomes in patients with ASD remains an open question. We examined the acute effects of prefrontal TMS on cortical excitability and fluid cognition in individuals with ASD who underwent TMS for refractory major depression.
View Article and Find Full Text PDFAn Enmeshed Family System? Jean Piaget as a Designated Therapist in 1920.
Integr Psychol Behav Sci
January 2025
Centre Jean Piaget, Université de Genève, Geneva, Switzerland.
Over the past century, numerous studies have examined Jean Piaget's relationship with psychoanalysis. Until the 1970s, they often emphasized the value of a rapprochement between Piaget and Freud and highlighted the use of Piaget's ideas in therapeutic practice. Then from the 1980s onwards, several studies focused on the relationship between his work-seen as purely cognitive, to the exclusion of the social and the affective-and his conflicted relationship with his mother.
View Article and Find Full Text PDFFrontal lobe intra-axial schwannoma harboring a CHD7::VGLL3 fusion and heterozygous TSC2 p.F1510del mutation in a young child.
Mol Biol Rep
January 2025
Department of Pathology and Laboratory Medicine, Baylor Scott and White Medical Center, Baylor College of Medicine, Temple, TX, USA.
Background: Brain intraparenchymal schwannoma is a rare clinical entity, generally curable with adequate resection.
Methods And Results: We describe a case in a male patient first presenting at 19 months of age, the youngest reported age for this lesion. It also appears to be the first case connected to a germline TSC2 p.
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