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Women and birth partners' experiences of cervical ripening at home and in hospital.
BMC Pregnancy Childbirth
January 2025
Centre for Maternal and Child Health Research, City St George's, University of London, Myddelton Street Building, 1 Myddelton Street, London, EC1R 1UB, United Kingdom.
Background: In the United Kingdom, induction of labour rates are rapidly rising, and around a third of pregnant women undergo the procedure. The first stage, cervical ripening, traditionally carried out in hospital, is increasingly offered outpatient - or 'at home'. The current induction of labour rates place considerable demand on maternity services and impact women's experiences of care, and at home cervical ripening has been suggested as potential solution for alleviating these.
View Article and Find Full Text PDFUser-Oriented Requirements for Artificial Intelligence-Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project.
JMIR Res Protoc
January 2025
Institute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.
Background: Artificial intelligence (AI)-based clinical decision support systems (CDSS) have been developed for several diseases. However, despite the potential to improve the quality of care and thereby positively impact patient-relevant outcomes, the majority of AI-based CDSS have not been adopted in standard care. Possible reasons for this include barriers in the implementation and a nonuser-oriented development approach, resulting in reduced user acceptance.
View Article and Find Full Text PDFAugmenting motion artifacts to enhance auto-contouring of complex structures in cone-beam computed tomography imaging.
Phys Med Biol
January 2025
Imaging Laboratory (iLab), Varian Medical Systems, Siemens Healthcare, Baden, Switzerland.
. To develop an augmentation method that simulates cone-beam computed tomography (CBCT) related motion artifacts, which can be used to generate training-data to increase the performance of artificial intelligence models dedicated to auto-contouring tasks.The augmentation technique generates data that simulates artifacts typically present in CBCT imaging.
View Article and Find Full Text PDFStudy on the construction of multi-level protection system for non-emergency transfer under the perspective of structuring.
Front Public Health
January 2025
School of Politics and Public Administration, Guangxi Minzu University, Nanning, Guangxi, China.
Introduction: The non-emergency transfer multi-level protection system is a pivotal livelihood endeavor in China, serving as a vital diversified component within the robust framework of a Chinese-style modern social security system. This system faces various challenges, including displacement of emergency capacity by non-emergency demands, uneven allocation of transfer resources, service quality variations, inadequate management structures, limited regulatory frameworks, and social acceptance issues.
Methods: Leveraging structural theory, this study analyzes the primary issues in the current implementation of China's non-emergency transfer security system.
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies.
Toxicol Pathol
January 2025
Eli Lilly and Company, Indianapolis, Indiana, USA.
Nonhuman primates (NHPs) have been and remain a highly valuable animal model with an essential role in translational research and pharmaceutical drug development. Based on current regulatory guidelines, the nonclinical safety of novel therapeutics should be evaluated in relevant nonclinical species, which commonly includes NHPs for biotherapeutics. Given the practical and ethical limitations on availability and/or use of NHPs and in line with the widely accepted guiding "3Rs" (replace, reduce, and refine) principles, many approaches have been considered to optimize toxicity study designs to meaningfully reduce the number of NHPs used.
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