Background: The diagnosis of infection (CDI) increases concern that asymptomatic carriers of toxigenic may be diagnosed with CDI.
Methods: A matched case control study was conducted in inpatients in a tertiary care center. The first 50 patients with diarrhea and a positive polymerase chain reaction (PCR) test beginning February 1, 2015, were identified as cases. Control patients were hospitalized patients receiving antibiotics, but with no diarrhea, housed in a room as close as possible to each case during the same admission time. A convenience sample of healthcare workers who cared for infected patients was also tested.
Results: We found two positive PCR results for in controls (4.1%). None of these healthcare workers were positive for by PCR. There was no difference between groups with respect to overall antibiotic use before the requested PCR for ( = 0.359). The majority of cases had a high proportion of gastrointestinal disorders (71.4%) compared with control (8.2%), < 0.001. Patients with neoplasia had a higher chance of being identified as cases ( = 0.041).
Conclusions: PCR should not be the only diagnostic tool but should be complementary to other methods and to the medical history.
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| http://dx.doi.org/10.1155/2017/5450829 | DOI Listing |
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