AI Article Synopsis
- In a study involving 55 lung cancer patients, researchers found that two imaging substances, F-FLT and F-FDG, showed different patterns of accumulation in cancer tissues. F-FLT attached mainly to rapidly dividing cancer cells, while F-FDG targeted oxygen-starved cells.
- Of the 24 confirmed malignant lesions, 79% exhibited mismatched accumulation of F-FLT and F-FDG, suggesting distinct tumor characteristics, while only 39% of the 31 benign lesions showed similar mismatches.
- The study concluded that the mismatch in distribution of F-FLT and F-FDG could serve as an important marker for identifying tumor behavior, with F-FDG indicating hypoxia and F-FLT indicating higher
Article Abstract
In a mouse model of human lung cancer, intratumoral distribution between 3'-deoxy-3'-[F] fluorothymidine (F-FLT) and [F] fluorodeoxyglucose (F-FDG) was mutually exclusive. F-FLT primarily accumulated in proliferating cancer cells, whereas F-FDG accumulated in hypoxic cancer cells. The aim of the present study was to evaluate these preclinical findings in patients with lung cancer. A total of 55 patients with solitary pulmonary lesion were included in the present study. Patients underwent F-FLT positron emission tomography-computed tomography (PET/CT) and F-FDG PET/CT scan with a 3-day interval. The final diagnosis was based on histological examination. Among the 55 cases, a total of 24 cases were confirmed as malignant lesions. Mismatched F-FLT- and F-FDG-accumulated regions were observed in 19 cases (79%) and matched in 5 (21%). Among the 31 benign lesions, F-FLT and F-FDG were mismatched in 12 cases (39%) and matched in 19 (61%). The difference in intratumoral distribution of F-FLT and F-FDG between malignant and benign lesions was statistically significant (P<0.05). The results of the present study indicate that a mismatch in intratumoral distribution of F-FLT and F-FDG may be a feature of patients with lung cancer. Increased F-FDG accumulation may serve as an indicator of tumor hypoxia, whereas regions with increased F-FLT uptake may be associated with an increased rate of cancer cell proliferation in patients with lung cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652252 | PMC |
| http://dx.doi.org/10.3892/ol.2017.6840 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of tumor-colonizing strains using the chick chorioallantoic membrane model.
mBio
January 2025
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
The chick embryo chorioallantoic membrane (CAM) tumor model is a valuable preclinical model for studying the tumor-colonizing process of serovar Typhimurium. It offers advantages such as cost-effectiveness, rapid turnaround, reduced engraftment issues, and ease of observation. In this study, we explored and validated the applicability of the partially immune-deficient CAM tumor model.
View Article and Find Full Text PDFIntratumor heterogeneity of HPV integration in HPV-associated head and neck cancer.
Nat Commun
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. Four HPV physical states were identified, with at least 49% of tumors progressing without integration.
View Article and Find Full Text PDFThe spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity.
Cell Rep
January 2025
Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain; Barcelona Supercomputing Center (BSC), Barcelona, Spain. Electronic address:
Tumors are complex ecosystems of interacting cell types. The concept of cancer hallmarks distills this complexity into underlying principles that govern tumor growth. Here, we explore the spatial distribution of cancer hallmarks across 63 primary untreated tumors from 10 cancer types using spatial transcriptomics.
View Article and Find Full Text PDFProtein-functionalized and intrinsically radiolabeled [Re]ReO nanoparticles: advancing cancer therapy through concurrent radio-photothermal effects.
Eur J Nucl Med Mol Imaging
January 2025
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
Purpose: Enhancing therapeutic effectiveness is crucial for translating anticancer nanomedicines from laboratory to clinical settings. In this study, we have developed radioactive rhenium oxide nanoparticles encapsulated in human serum albumin ([Re]ReO-HSA NPs) for concurrent radiotherapy (RT) and photothermal therapy (PTT), aiming to optimize treatment outcomes.
Methods: [Re]ReO-HSA NPs were synthesized by a controlled reduction of ReO in HSA medium and extensively characterized.
Multivalent ionizable lipid-polypeptides for tumor-confined mRNA transfection.
Bioact Mater
April 2025
Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymers, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
mRNA therapeutics is revolutionizing the treatment concepts toward many diseases including cancer. The potential of mRNA is, however, frequently limited by modest control over site of transfection. Here, we have explored a library of multivalent ionizable lipid-polypeptides (MILP) to achieve robust mRNA complexation and tumor-confined transfection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!