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Blood-based DNA methylation markers for lung cancer prediction.
BMJ Oncol
May 2024
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.
Objective: Screening high-risk individuals with low-dose CT reduces mortality from lung cancer, but many lung cancers occur in individuals who are not eligible for screening. Risk biomarkers may be useful to refine risk models and improve screening eligibility criteria. We evaluated if blood-based DNA methylation markers can improve a traditional lung cancer prediction model.
View Article and Find Full Text PDFEnergetic constraints drive the decline of a sentinel polar bear population.
Science
January 2025
Laboratory of Quantitative Global Change Ecology, Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada.
Human-driven Arctic warming and resulting sea ice loss have been associated with declines in several polar bear populations. However, quantifying how individual responses to environmental change integrate and scale to influence population dynamics in polar bears has yet to be achieved. We developed an individual-based bioenergetic model and hindcast population dynamics across 42 years of observed sea ice conditions in Western Hudson Bay, a region undergoing rapid environmental change.
View Article and Find Full Text PDFMetabolomics-Guided Discovery of Bipolarolides H-O, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus sp. nov.
J Nat Prod
January 2025
Marbio, Norwegian College of Fishery Science (NFH), Faculty of Biosciences, Fisheries, and Economics, UiT-The Arctic University of Norway, Tromsø 9037, Norway.
Article Synopsis
- A new species of Pleosporales fungus was isolated from driftwood and cultivated to explore potential new secondary metabolites.
- The study identified eight new compounds called ophiobolin-type sesterterpenes, known as bipolarolides H-O, using a combination of HPLC-MS and spectroscopic methods.
- Three of these bipolarolides demonstrated inhibitory activity against certain organisms, with MIC values indicating their potency.
Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.
Risk Manag Healthc Policy
January 2025
Université Paris Cité, Inserm U1266, Institut de Psychiatrie et Neurosciences de Paris (IPNP), Team Vulnerability of Psychiatric and Addictive Disorders, Paris, France.
Purpose: Alcohol use is a leading risk factor for preventable death, injury, and disease globally. Low sensitivity to the effects of alcohol is influenced by genes and predicts risk for harmful alcohol use and alcohol use disorder (AUD). Alcohol induces effects partly by modulation of gamma-aminobutyric acid receptors type A (GABARs).
View Article and Find Full Text PDFSpatiotemporal variation in size-dependent growth rates in small isolated populations of Arctic charr ().
R Soc Open Sci
January 2025
School of Biology, University of St Andrews, St Andrews, UK.
As a key life-history trait, growth rates are often used to measure individual performance and to inform parameters in demographic models. Furthermore, intraspecific trait variation generates diversity in nature. Therefore, partitioning out and understanding drivers of spatiotemporal variation in growth rate is of fundamental interest in ecology and evolution.
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