The stocking of antidotes in various care settings is a subject of debate. A group of experts in hospital pharmacy and both adult and pediatric clinical toxicology was formed to review the Spanish and international literature on the subject with the aim of updating recommendations about which antidotes to stock and in what amounts in hospitals of different levels of complexity. The experts also considered the usual indications for the use of antidotes and dosing. The amount to have on hand was defined as enough to treat an adult weighing 70 kg for 24 hours (or 3 such adults in an A-level hospital; ie, a highly complex center or the reference hospital for an area). The group also listed 34 antidotes that B-level hospitals should stock and 22 that other types of hospital should stock. The recommendations also provide a guide for using the antidotes in the forms of presentation available in Spain in 2015, a list of their main indications and recommended doses, and specific notes on each.
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STAR Protoc
January 2025
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address:
Tumor Treating Fields (TTFields) are electric fields clinically approved for cancer treatment, delivered via arrays attached to the patient's skin. Here, we present a protocol for applying TTFields to torso orthotopic and subcutaneous mouse tumor models using the inovivo system. We guide users on proper system component connections, study protocol design, mouse fur depilation, array application, and treatment condition adjustment and monitoring.
View Article and Find Full Text PDFAn experiment was conducted for 60 days in a 500L capacity FRP tank containing inland ground saline water (fortified to a level of 50% potassium) with one control (sediment) and three treatments; T1(Paddy Straw Biochar (PSB) in sediment), T2 (Banana Peduncle Biochar (BPB) in sediment), and T3 (PSB + BPB in sediment). Biochar (100 g) was amended with sediment (25 kg) at 9 tons/ha. Shrimps of average weight 5 ± 0.
View Article and Find Full Text PDFClin Toxicol (Phila)
January 2025
Minnesota Regional Poison Center, Minneapolis, MN, USA.
Introduction: Sodium nitrite is a potent oxidizer, which may precipitate rapidly lethal methemoglobinemia. Prompt diagnosis and treatment may salvage otherwise fatal cases. It is unclear if emergency departments are prepared for increasing cases.
View Article and Find Full Text PDFSci Total Environ
December 2024
Soil Biogeochemistry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Organic soil amendments (OSA) with long residence times, such as biochar, have a high potential for soil organic carbon (SOC) sequestration. The highly aromatic structure of biochar reduces microbial decomposition and explains the slow turnover of biochar, indicating long persistence in soils and thus potential SOC sequestration. However, there is a lack of data on biochar-induced SOC sequestration in the long-term and under field conditions.
View Article and Find Full Text PDFOncologist
December 2024
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United States.
Background: Doublet platinum or taxane-based therapies are the current standard backbone of treatment for advanced gastric/gastroesophageal junction (GEJ) adenocarcinoma. Previously used anthracycline-based triplet regimens are no longer used routinely due to toxicity and lack of superior efficacy. We hypothesized that the addition of nab-paclitaxel to FOLFOX (FOLFOX-A) would induce higher efficacy and better tolerability.
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