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Gene-nutrient interactions and susceptibility to human obesity. | LitMetric

Gene-nutrient interactions and susceptibility to human obesity.

Genes Nutr

Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001 USA.

Published: October 2017

AI Article Synopsis

Article Abstract

A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with common human obesity. The mounting evidence suggests that these obesity gene variants interact with multiple environmental factors and increase susceptibility to this complex metabolic disease. The objective of this review article is to provide concise and updated information on energy balance, heritability of body weight, origins of gene variants, and gene-nutrient interactions in relation to human obesity. It is proposed that knowledge of these related topics will provide valuable insight for future preventative lifestyle intervention using targeted nutritional and medicinal therapies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663124PMC
http://dx.doi.org/10.1186/s12263-017-0581-3DOI Listing

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