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Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration.
Int J Mol Sci
December 2024
Central Research Institute of Dentistry and Maxillofacial Surgery, 119021 Moscow, Russia.
The use of 3D-printed gene-activated bone grafts represents a highly promising approach in the fields of dentistry and orthopedics. Bioresorbable poly-lactic-co-glycolic acid (PLGA) scaffolds, infused with adenoviral constructs that carry osteoinductive factor genes, may provide an effective alternative to existing bone grafts for the reconstruction of extensive bone defects. This study aims to develop and investigate the properties of 3D scaffolds composed of PLGA and adenoviral constructs carrying the BMP2 gene (Ad-BMP2), both in vitro and in vivo.
View Article and Find Full Text PDFEnhancing percutaneous coronary intervention using TriVOCTNet: a multi-task deep learning model for comprehensive intravascular optical coherence tomography analysis.
Phys Eng Sci Med
January 2025
Faculty of Engineering, Department of Biomedical Engineering, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- Neointimal coverage and stent apposition are critical for improving percutaneous coronary interventions (PCI), but current algorithms struggle with automating the analysis of diverse stent types and preselecting necessary segments.
- This study introduces TriVOCTNet, a multi-task deep learning model designed to automate the classification, lumen segmentation, and stent strut segmentation in IVOCT images, all within one efficient network.
- TriVOCTNet demonstrated impressive accuracy with high classification rates and precise segmentation outputs, indicating its potential for enhancing clinical practices in PCI procedures.
Background: Failure after rotator cuff repair is typically due to a loss of integrity of the bone-tendon interface. The BioWick anchor (Zimmer-Biomet) is an interpositional scaffold-anchor that was developed to improve tendon-bone healing. The purpose of this study was to determine the clinical efficacy of this novel anchor compared with a standard anchor with respect to retear rates and patient outcomes.
View Article and Find Full Text PDFCurrent situation and overview of resorbable magnesium scaffolds: a perspective for overcoming the remaining issues of polymeric bioresorbable scaffold.
Cardiovasc Interv Ther
December 2024
Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Saitama, 330-8503, Japan.
Bioresorbable scaffolds (BRS) were developed as an innovative solution to overcome the limitations of metallic stents. While polymeric BRS initially demonstrated comparable clinical outcomes to drug-eluting stent (DES) in clinical trials, subsequent large-scale studies revealed that patients implanted with polymeric BRS experienced higher rates of scaffold thrombosis (ScT) and target lesion failure compared to those with metallic stents. Resorbable magnesium scaffolds (RMS) have emerged as a promising alternative owing to magnesium's natural degradability and favorable mechanical properties.
View Article and Find Full Text PDFThe Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration.
Int J Mol Sci
November 2024
Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, 05-552 Magdalenka, Poland.
Bone defects and fractures present significant clinical challenges, particularly in orthopedic and maxillofacial applications. While minor bone defects may be capable of healing naturally, those of a critical size necessitate intervention through the use of implants or grafts. The utilization of traditional methodologies, encompassing autografts and allografts, is constrained by several factors.
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