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Ability of calcium-entry blockade by felodipine to disclose different pathogenetic mechanisms behind hyperventilation-induced myocardial ischemia in men.
Am J Cardiol
December 1990
Division of Cardiology, IRCCS, Policlinico S. Matteo, University of Pavia, Italy.
To verify that myocardial ischemia occurring during either the overbreathing or recovery phase of the hyperventilation test is based on different pathogenetic mechanisms, 2 consecutive series of patients, selected on the basis of their response to a run-in hyperventilation test, were studied. Group I comprised 15 patients who developed ST-segment depression early during overbreathing, whereas group II consisted of 12 patients showing ST-segment depression late during the recovery phase. A single oral dose of felodipine 10 mg or of placebo was administered on 2 consecutive days according to a randomized, double-blind, crossover design, and the hyperventilation test was repeated, on both days of the study, 3 to 5 hours after drug intake.
View Article and Find Full Text PDFEffect of felodipine on hyperventilation-induced ischemic attacks in variant angina pectoris.
Am J Cardiol
January 1989
Divisione di Cardiologia, Università degli Studi di Pavia, Italy.
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