AI Article Synopsis
- B cells are essential for the immune system, particularly in combating various infectious diseases through long-lasting antibody production.
- Some chronic infections, like those caused by Leishmania and Trypanosoma spp., can disrupt normal B cell functions, leading to ineffective immune responses.
- The review discusses how these parasites manipulate B cell activity, causing issues like nonspecific antibody production and reduced B cell survival, which contribute to ongoing infections and immune-related problems.
Article Abstract
B cells are notorious actors for the host's protection against several infectious diseases. So much so that early vaccinology seated its principles upon their long-term protective antibody secretion capabilities. Indeed, there are many examples of acute infectious diseases that are combated by functional humoral responses. However, some chronic infectious diseases actively induce immune deregulations that often lead to defective, if not deleterious, humoral immune responses. In this review we summarize how Leishmania and Trypanosoma spp. directly manipulate B cell responses to induce polyclonal B cell activation, hypergammaglobulinemia, low-specificity antibodies, limited B cell survival, and regulatory B cells, contributing therefore to immunopathology and the establishment of persistent infections.
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| http://dx.doi.org/10.1016/j.pt.2017.10.001 | DOI Listing |
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