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Geometrically constrained cytoskeletal reorganisation modulates DNA nanostructures uptake.
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Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, Prague, 18200, Czech Republic.
DNA nanostructures (DNs) have gained popularity in various biomedical applications due to their unique properties, including structural programmability, ease of synthesis and functionalization, and low cytotoxicity. Effective utilization of DNs in biomedical applications requires a fundamental understanding of their interactions with living cells and the mechanics of cellular uptake. Current knowledge primarily focuses on how the physicochemical properties of DNs, such as mass, shape, size, and surface functionalization, affect uptake efficacy.
View Article and Find Full Text PDFPhysical activity-the past, present and potential future: a state-of-the-art review.
Health Promot Int
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Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, 117549,Singapore.
This is a state-of-the-art review of historical developments, current approaches and recommended future directions in physical activity (PA) research, practice and policy. Since the early epidemiological studies in the 1950s, PA research has developed from within a biomedical paradigm. There is now a strong evidence base linking PA with positive health outcomes.
View Article and Find Full Text PDFPositive selection on mammalian immune genes-effects of gene function and selective constraint.
Mol Biol Evol
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Department of Biology, Lund University, Kontaktvägen 10, 223 62 Lund, Sweden.
Genome-wide analyses of various taxa have repeatedly shown that immune genes are important targets of positive selection. However, little is known about what factors determine which immune genes are under positive selection. To address this question, we here focus on the mammalian immune system and investigate the importance of gene function and other factors like gene expression, protein-protein interactions, and overall selective constraint as determinants of positive selection.
View Article and Find Full Text PDFStrengthening public health education and humanitarian response through academic volunteerism.
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Canadian Institute of Health Research- Health Systems Impact Fellow, Canadian Red Cross, Ottawa, Canada.
Introduction: Volunteers are an integral part of the International Red Cross and Red Crescent (RCRC) Movement, with over 16 million people actively contributing to humanitarian action worldwide. Academic volunteerism within the Movement includes contributions from students, volunteers and professionals from academic institutions who offer their time and expertise. In this study we aimed to understand the process of embedding academic volunteers in humanitarian organizations such as the Canadian Red Cross (CRC) and assess the impact of their activities within the realm of public health education.
View Article and Find Full Text PDFInvestigating assumptions in motivational interviewing among general practitioners: a qualitative study.
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Department of General Practice, University of Western Brittany, 22, Av. Camille Desmoulins, FR 29238, Brest, France.
Background: Unhealthy behaviours contributing to cardiovascular issues, diabetes, strokes, and cancer, pose significant health risks. General practitioners (GPs) are pivotal in guiding behaviour change, with Motivational Interviewing (MI) showing promise. MI, developed by William Miller and Stephen Rollnick, aims to enhance motivation for change.
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