To better protect soldiers from blast threat, that principally affect air-filled organs such a lung, it is necessary to develop an adapted injury criterion and, prior to this, to evaluate the response of a biological model against that threat. The objective of this study is to provide some robust data to quantify the chest response of post-mortem swine under blast loadings. 7 post-mortem swine (54.5 ± 2.6 kg), placed side-on to the threat and against the ground, were exposed to 5 shock-waves of increasing intensities. Their thorax were instrumented with a piezo-resistive pressure sensor, an accelerometer directly exposed to the shock-wave and a target was mounted on the latter in order to track the chest wall displacement. For incident impulses ranging from 47 kPa ms±2% to 173 kPa ms ±6%, the measured maximum of linear chest wall acceleration (Γmax) goes from 5800 m/s ±16% to 41,000 m/s ± 8%, with a duration of 0.8 ms. Chest wall displacements ranging from 5 mm ± 20% to 20 mm ± 15%, with a duration of 9 ms, are reached. These reproducible data were used to find simple relations (linear, 2nd and 3rd order polynomials) between the kinematic parameters (plus the viscous criterion) and the incident and reflected impulses. Correlating the new reproducible data with the prediction from the Bowen curves showed a lung injury threshold in terms of Γmax similar to that of Cooper (10,000 m/s). However, the limits defined for the viscous criterion in the automobile field and for non-lethal weapons seems not adapted for the blast threat.
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http://dx.doi.org/10.1016/j.jbiomech.2017.10.012 | DOI Listing |
Cells
December 2024
Institute of Anaesthesiologic Pathophysiology and Process Development, University Hospital Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
Commun Biol
January 2025
AngioRhythms in Health and Disease, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Liver sinusoidal endothelial cells (LSECs) critically regulate homeostatic liver function and liver pathogenesis. However, the isolation of LSECs remains a major technological bottleneck in studying molecular mechanisms governing LSEC functions. Current techniques to isolate LSECs, relying on perfusion-dependent liver digestion, are cumbersome with limited throughput.
View Article and Find Full Text PDFJ Vet Res
December 2024
Department of Parasitology and Invasive Diseases, National Veterinary Research Institute, 24-100 Puławy, Poland.
Introduction: This article presents the fourth detection of macroscopic cystic lesions due to sarcocystosis in domestic pigs during routine meat inspection worldwide, and the first molecular detection of in a domestic pig in Poland. Pigs can become intermediate hosts for by accidental ingestion of oocysts or sporocysts present in food or water contaminated by the faeces of canids (definitive hosts).
Material And Methods: The affected swine showed no clinical symptoms such as weight loss, dermatitis or dyspnoea suggesting sarcocystosis.
Am J Physiol Heart Circ Physiol
December 2024
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Chronic kidney disease (CKD) is on the rise, and over 50% of patients die from cardiac causes. Patients develop heart failure due to unelucidated reno-cardiac interactions, termed type 4 cardiorenal syndrome (CRS4). The aim of this study is to establish and characterize a reliable model of CRS4 in swine with marked cardiac diastolic dysfunction.
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December 2024
ICAR-National Research Centre on Pig, Rani, Guwahati, 781131, Assam, India.
Porcine reproductive and respiratory syndrome (PRRS) is a significant swine disease with no effective vaccine due to high viral mutation rates. This study investigates a natural PRRS outbreak through molecular, pathological, and serological analyses. Nineteen affected pigs were clinically examined, and 10 underwent post-mortem examination.
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