AI Article Synopsis
- Recent discoveries highlight important pathways for lipid trafficking in cells, involving both vesicular (like transport vesicles) and non-vesicular (like transfer proteins) methods.
- Understanding how these different pathways contribute to cell growth and the formation of organelles is still a challenge due to the complex flow of lipids from various sources.
- This discussion aims to share current insights and raise questions about the mechanisms of lipid transport that are crucial for expanding membranes during organelle development and overall cell growth.
Article Abstract
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663033 | PMC |
| http://dx.doi.org/10.1186/s12915-017-0432-0 | DOI Listing |
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