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Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22 Philadelphia Chromosome-Negative B-Cell Precursor Acute Lymphoblastic Leukemia.
J Clin Oncol
December 2024
Division of Hematology, Centre Hospitalier de Versailles, Université Versailles Paris-Saclay, Le Chesnay, France.
Purpose: The use of inotuzumab ozogamicin (InO), a conjugated anti-CD22 monoclonal antibody, is becoming a promising frontline treatment for older patients with ALL.
Patients And Methods: EWALL-INO is an open-label prospective multicenter phase II trial (ClinicalTrials.gov identifier: NCT03249870).
Knowing "what for," but not "where": Dissociation between functional and contextual tool knowledge in healthy individuals and patients with dementia.
J Int Neuropsychol Soc
February 2024
Laboratoire de Psychologie des Pays de la Loire (EA 4638), Université d'Angers, Angers, France.
Objective: Semantic tool knowledge underlies the ability to perform activities of daily living. Models of apraxia have emphasized the role of functional knowledge about the action performed with tools (e.g.
View Article and Find Full Text PDF[Towards teaching eco-design of care in the initial training of future health professionals].
Soins
May 2023
École des hautes études en santé publique, 15 avenue du Professeur-Léon-Bernard, CS 74312, 35043 Rennes cedex, France. Electronic address:
Our society is regularly faced with new dangers, linked to the evolution of living conditions, production, work, consumption and housing. Health systems are no stranger to this. On the contrary, they have a real impact on the environment, which needs to be mitigated.
View Article and Find Full Text PDFMeaningless imitation in neurodegenerative diseases: Effects of body part, bimanual imitation, asymmetry, and body midline crossing.
Cogn Neuropsychol
May 2023
Univ Angers, Université de Nantes, LPPL, SFRCONFLUENCES, Angers, France.
Visuo-imitative apraxia has been consistently reported in patients with dementia, yet there have been substantial methodological differences between studies, while multiple, sometimes competing hypotheses have been put forward to explain this syndrome. Our goals were to study specific imitation deficits in groups of patients who have been selected and assigned to a group solely based on clinical criteria. We tested the effects of body part, bimanual imitation, asymmetry of the model, and body midline crossing, in patients with cortical atrophy of the temporal lobes (semantic dementia, SD), frontal-parietal networks (FPN, i.
View Article and Find Full Text PDFAs soon as there was life, there was danger: the deep history of survival behaviours and the shallower history of consciousness.
Philos Trans R Soc Lond B Biol Sci
February 2022
Center for Neural Science, New York University, New York, NY 10003, USA.
It is often said that fear is a universal innate emotion that we humans have inherited from our mammalian ancestors by virtue of having inherited conserved features of their nervous systems. Contrary to this common sense-based scientific point of view, I have argued that what we have inherited from our mammalian ancestors, and they from their distal vertebrate ancestors, and they from their chordate ancestors, and so forth, is not a fear circuit. It is, instead, a defensive survival circuit that detects threats, and in response, initiates defensive survival behaviours and supporting physiological adjustments.
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