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Viscoelastic hydrogel combined with dynamic compression promotes osteogenic differentiation of bone marrow mesenchymal stem cells and bone repair in rats.
Regen Biomater
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Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, PR China.
A biomechanical environment constructed exploiting the mechanical property of the extracellular matrix and external loading is essential for cell behaviour. Building suitable mechanical stimuli using feasible scaffold material and moderate mechanical loading is critical in bone tissue engineering for bone repair. However, the detailed mechanism of the mechanical regulation remains ambiguous.
View Article and Find Full Text PDFBacterial-host adhesion dominated by collagen subtypes remodelled by osmotic pressure.
NPJ Biofilms Microbiomes
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Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China.
Environmental osmolarity plays a crucial role in regulating the functions and behaviors of both host cells and pathogens. However, it remains unclear whether and how environmental osmotic stimuli modulate bacterial‒host interfacial adhesion. Using single-cell force spectroscopy, we revealed that the interfacial adhesion force depended nonlinearly on the osmotic prestimulation of host cells but not bacteria.
View Article and Find Full Text PDFFSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.
Comput Methods Appl Mech Eng
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Department of Pediatrics - Cardiology, Stanford Univeristy, Stanford, CA 94305, USA.
Equilibrated fluid-solid-growth (FSGe) is a fast, open source, three-dimensional (3D) computational platform for simulating interactions between instantaneous hemodynamics and long-term vessel wall adaptation through mechanobiologically equilibrated growth and remodeling (G&R). Such models can capture evolving geometry, composition, and material properties in health and disease and following clinical interventions. In traditional G&R models, this feedback is modeled through highly simplified fluid solutions, neglecting local variations in blood pressure and wall shear stress (WSS).
View Article and Find Full Text PDFComputationally derived endosteal strain and strain gradients correlate with increased bone formation in an axially loaded murine tibia model.
J Mech Behav Biomed Mater
December 2024
School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, USA; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA. Electronic address:
Article Synopsis
- * Rodent models, particularly using mouse tibia, have proven essential for studying how mechanical loading affects bone adaptation through techniques like microCT-based finite element modeling and strain gauge measurements.
- * The study found that strains in cancellous bone were lower than in cortical bone, with cortical bone's properties being the most influential factor, linking computational models of strain to actual bone formation observed through histomorphometry analysis.
Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Interpenetrating Networks.
Adv Mater
November 2024
Department of Bioengineering, University of Washington, Seattle, WA, 98105, USA.
Biomechanical contributions of the extracellular matrix underpin cell growth and proliferation, differentiation, signal transduction, and other fate decisions. As such, biomaterials whose mechanics can be spatiotemporally altered- particularly in a reversible manner- are extremely valuable for studying these mechanobiological phenomena. Herein, a poly(ethylene glycol) (PEG)-based hydrogel model consisting of two interpenetrating step-growth networks is introduced that are independently formed via largely orthogonal bioorthogonal chemistries and sequentially degraded with distinct recombinant sortases, affording reversibly tunable stiffness ranges that span healthy and diseased soft tissues (e.
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