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Infantile occult exposure to cocaine in domestic environments represents a complex clinical and medico-legal problem, which can be associated with abuse and neglect and with potential short- and long-term health risks for children. The authors present a retrospective study on 764 children under 14 years old who accessed the Emergency Department of IRCCS Meyer from 2016 to 2023 and were included in the GAIA (Child and Adolescent Abuse Group) protocol for suspected maltreatment and abuse, and for which a urine toxicology analysis was performed. The aim is to discuss the medico-legal implications and highlight the need for a thorough evaluation and management of such situations.

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Article Synopsis
  • Researchers need to find out what factors might put babies at risk of being taken out of their homes, especially due to their parents' substance use.
  • In a study with 1,808 parent-baby pairs, most of the parents were Non-Hispanic White, and many babies were exposed to drugs like alcohol and opioids before birth.
  • The study found that many babies with drug exposure didn't get to go home with their parents, and understanding how substance use affects placement decisions can help improve support for families in need.
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Prenatal and postnatal cocaine exposure enhances the anxiety- and depressive-like behaviors in rats: An ontogenetic study.

Int J Dev Neurosci

October 2024

Subdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Mexico City, Mexico.

Article Synopsis
  • * Cocaine was administered to pregnant rats, and their male offspring were later tested for anxiety and depressive behaviors at 30, 60, 90, and 120 days old.
  • * Results showed that the negative effects of cocaine exposure on mood-related behaviors increased with age, being most pronounced in older adult rats.
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Increasing evidence indicates that prenatal cocaine exposure may result in many developmental and long-lasting neurological and behavioral effects. The behaviors of female animals are strongly associated with the estrous cycle. Estrogen receptors and oxytocin are important neuroendocrine factors that regulate social behavior and are of special relevance to females.

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Article Synopsis
  • Cannabis use in Canada rose from 1.5% to 2.5% between 2012 and 2019, prompting studies on prenatal cannabis exposure and its potential impacts on birth weight and neurodevelopment, complicated by various factors.
  • Research utilizing animal models, specifically a study with mice, controls for dose and timing by exposing mothers to THC through a peanut butter diet during pregnancy and early postnatal life.
  • Findings revealed that male offspring had altered VTA dopamine neuron activity but exhibited no changes in cocaine-seeking behavior, indicating that prenatal cannabis exposure can impact neurodevelopment in a sex-specific manner.
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