Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Harvey Cushing: France Military Hospital Surgical Unit Head and World War I U.S. Army Medical Corps Commissioner.
World Neurosurg
January 2025
Department of Neurosurgery, New York University Grossman School of Medicine, New York City, New York City, USA.
Background: This historical account reviews the course and lasting impact of Dr. Harvey Cushing (1869-1939) in neurosurgery.
Methods: The writing of this project was sparked by the discovery of original scientific and bibliographical information about Cushing.
Analysis of historical data to accelerate deletion of Abnormal Toxicity Test requirement for biologicals and vaccines.
Toxicol Rep
December 2024
National Institute of Biologicals, Ministry of Health and Family Welfare, Noida, Uttar Pradesh 201309, India.
Abnormal Toxicity Test (ATT) is performed as quality control test by manufacturers and National Control Laboratory (NCL) to ensure safety of biologicals. However, stakeholders are in general consensus that extraneous toxic contaminations are extremely unlikely where Good Manufacturing Practices (GMPs) and consistent production have been established. This test requiring mice and guinea pigs is still a regulatory requirement for the batch release of biologicals in several countries although it has been deleted by some National Regulatory Authorities (NRAs) and Pharmacopoeias while some are still working on its elimination.
View Article and Find Full Text PDFDevelopment and Evaluation of Lactose-Free Single-Unit and Multiple-Unit Preparations of a BCS Class II Drug, Rivaroxaban.
Pharmaceutics
November 2024
Department of Pharmaceutics and Biopharmaceutics, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
: The aim of the present study was to develop lactose-free formulations of rivaroxaban, a novel oral anticoagulant used for the treatment and prevention of blood clotting. As a BCS Class II drug, rivaroxaban is characterized by poor solubility in aqueous media, posing a significant formulation challenge. : To address this, phosphate-based excipients were employed to prepare both traditional single-unit dosage forms (tablets) and modern multiple-unit pellet systems (MUPS).
View Article and Find Full Text PDFSide-effects of Phytotherapeutics in Cancer Care - A Review of Inconsistencies in National and International Databases.
Anticancer Res
October 2024
Department of Internal Medicine II, Haematology and Internal Oncology, University Hospital Jena, Jena, Germany.
Background/aim: The interest in phytotherapy in patients with cancer is immensely high. When using herbal medicine, knowledge of potential side-effects is essential as part of counselling the patient. The aim of this study was therefore to collect information on the side-effects of popular medicinal plants and to compare different official and the most popular sources of information reporting the side-effects of phytotherapeutics.
View Article and Find Full Text PDFManaging Risk When Working with Orbiviruses with a Special Emphasis on Epizootic Hemorrhagic Disease Virus.
Methods Mol Biol
August 2024
The Pirbright Institute, Woking, UK.
Risk assessment is the cornerstone of working safely with biological agents. The World Health Organization (WHO) Laboratory Biosafety Manual Fourth Edition Monograph on Risk Assessment provides stepwise guidance for completing a risk assessment, from information gathering and identifying hazards to evaluating the risks, developing, and implementing controls and review.To support the development of a mature safety culture within laboratories, it is important that all staff who handle biological agents understand the fundamentals of risk assessment and receive training in identifying hazards created by their work activities (or tasks) and understand how to mitigate the risks arising from carrying out that work.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!