The data presented in this article are related to the research article entitled "Isobarictags for relative and absolute quantitation (iTRAQ) -based proteomics for the investigation of the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats" (Yao et al., 2017) [1]. This article describes the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats at the level of the proteome (HFD: control, HH: control, HH: HFD, respectively). The field dataset is available to criticize or extended analyzes in public.
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| http://dx.doi.org/10.1016/j.dib.2017.10.027 | DOI Listing |
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[Effects of sera of rats fed with tablets on endoplasmic reticulum stress in a HepG2 cell model of nonalcoholic fatty liver disease].
Nan Fang Yi Ke Da Xue Xue Bao
November 2018
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Objective: To investigate the effects of sera from rats fed with tablets (HGT) on endoplasmic reticulum (ER) stress in a steatotic hepatocyte model of free fatty acids (FFAs)-induced nonalcoholic fatty liver disease (NAFLD) and explore the possible mechanism.
Methods: FFAs prepared by mixing oleic acid and palmitic acid at the ratio of 2:1. HepG2 cells were treated with the sera from rats fed with low-, moderate-or high-dose HGT (HGT sera) or sera of rats fed with fenofibrate (fenofibrate sera), followed by treatment with 1 mmol/L FFAs for 24 h to induce hepatic steatosis.
Data for iTRAQ-based quantification of the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats.
Data Brief
December 2017
Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong, PR China.
The data presented in this article are related to the research article entitled "Isobarictags for relative and absolute quantitation (iTRAQ) -based proteomics for the investigation of the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats" (Yao et al., 2017) [1]. This article describes the effect of HuganQingzhi on non-alcoholic fatty liver disease in rats at the level of the proteome (HFD: control, HH: control, HH: HFD, respectively).
View Article and Find Full Text PDF[Establishment of a L-02 cell model of hepatic steatosis].
Nan Fang Yi Ke Da Xue Xue Bao
June 2014
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.E-mail:
Objective: To establish an in vitro cell model for investigating hepatic steatosis in non-alcoholic fatty liver disease.
Methods: L-02 cells cultured in 1640 containing 10% fetal bovine serum were divided into control group and model group. At 70%-80% confluency, L-02 cells in the model group were exposed to a long-chain mixture of free fatty acids (FFA, oleate and palmitate ) for 24 h, and cells in control group were treated with fresh medium.
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