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Clozapine-Associated Pisa Syndrome: A Case Report of an Acute Reaction in a Bipolar Patient.
Clin Neuropharmacol
November 2021
Hospital Júlio de Matos, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal.
Article Synopsis
- The study focuses on a 73-year-old woman with bipolar disorder who developed Pisa syndrome (PS) after starting clozapine, a medication often used for severe psychiatric conditions.
- Pisa syndrome is a rare type of dystonia that can arise from neuroleptic medications, linked with clozapine though it has a lower risk compared to other antipsychotics.
- Effective management of clozapine-induced PS involves reducing or stopping the medication, and reporting such cases can help in better understanding the risks and characteristics of this syndrome.
Association between the glyco-metabolic adverse effects of antipsychotic drugs and their chemical and pharmacological profile: a network meta-analysis and regression.
Psychol Med
February 2021
Scientific institute IRCCS E. Medea, Bosisio Parini, LC, 23892, Italy.
Article Synopsis
- Long-term use of antipsychotic medications can cause problems with metabolism, like diabetes, but it’s not clear why or how bad they can be.
- Researchers looked at many studies to see which antipsychotics cause the most and least metabolic issues, finding that olanzapine and clozapine are the worst, while aripiprazole and ziprasidone are better.
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Clozapine-associated Pisa syndrome: A rare type of tardive dystonia.
Indian J Psychiatry
January 2017
Department of Psychiatry, KMCT Medical College, Calicut, Kerala, India. E-mail:
Reversible Pisa syndrome induced by clozapine: a case report.
Clin Neuropharmacol
February 2008
Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Pisa syndrome, manifested with persistent lateral flexion of the trunk, is most commonly associated with prolonged treatment with typical antipsychotics. However, it was also reported as occurring with atypical antipsychotics. To our knowledge, there have been very few reports of clozapine-associated Pisa syndrome.
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