Introduction: It is important to know the effective dose from computed tomography (CT) examinations. The aim of this study was to evaluate the effective dose from pediatric CT examinations in Iceland.
Materials And Method: For all pediatric CT exams (children < 18 years) performed during one year (1.2.2016 till 1.2.2017), data on age, examination type and dose length product was retrospectively collected from the Landspitali University Hospital's archives, as was the total number of CT examinations. The ratio of pediatric CT exams and the frequency of examination types were calculated and, for the three most common examinations, the effective dose and mean dose length product were calculated for five age groups.
Results: The total number of pediatric CT examinations was 662, 3,6% of all the CT examinations performed. The three most common pediatric CT examinations were head (40,3%), abdomen (15,6%) and thorax (10,3%). The mean effective dose in those was, in the above order: for children < 4 months: 5,3/4,9/3,0 mSv; 4 months to < 3 years: 4,2/5,5/1,9 mSv; 3 years to < 8 years: 2,7/ 3,4/1,0 mSv; 8 years to < 15 years: 3,2/4,4/1,0 mSv and 15 years to < 18 years: 2,1/6,5/3,3 mSv. The mean dose length product was above European diagnostic reference levels in most examination types and age groups.
Conclusion: Possibilities for lower effective doses from pediatric CT examinations should be explored. For that purpose, the use of size specific dose estimates is recommended.
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http://dx.doi.org/10.17992/lbl.2017.11.160 | DOI Listing |
ACS Nano
January 2025
Department of Gynecology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China.
Recent research has demonstrated that activating the cGAS-STING pathway can enhance interferon production and the activation of T cells. A manganese complex, called TPA-Mn, was developed in this context. The reactive oxygen species (ROS)-sensitive nanoparticles (NPMn) loaded with TPA-Mn are developed.
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Sidney Kimmel Medical College at Thomas Jefferson University and Jefferson Einstein Hospital, Philadelphia, Pennsylvania.
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View Article and Find Full Text PDFACR Open Rheumatol
January 2025
Duke University and Duke Clinical Research Institute, Durham, North Carolina.
Objective: The objective of this study was to evaluate the preliminary effectiveness of an electronic pill bottle with automated reminders on hydroxychloroquine (HCQ) adherence in children with pediatric systemic lupus erythematosus (pSLE).
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Biomol Concepts
January 2025
Division of Pharmacology, School of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.
Seaweeds have been utilized as food, fodder, fertilizer, and medicine since ancient times; nevertheless, they have received only a little attention. In the current work, we extracted the sulfated polysaccharide from a marine source and investigated its anti-arthritic potential . The isolated and freeze-dried polysaccharide was tested for acute oral toxicity based on OECD 423.
View Article and Find Full Text PDFPharm Stat
January 2025
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
A recent study design for clinical trials with small sample sizes is the small n, sequential, multiple assignment, randomized trial (snSMART). An snSMART design has been previously proposed to compare the efficacy of two dose levels versus placebo. In such a trial, participants are initially randomized to receive either low dose, high dose or placebo in stage 1.
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