Treatment Outcome of Ovulation-inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study.

Objective: To compare different treatment regimens on pregnancy rate and outcome in patients with anovulatory infertility.

Patients And Methods: A prospective observational study was conducted on patients with infertility due to anovulation. Patients treated with clomiphene citrate (CC) 50/100 mg/day from 2 to 6 day of menstrual cycle (MC) ( = 38), short gonadotropin-releasing hormone (GnRH) agonist regimen (leuprolide [0.5 mg subcutaneous] + recombinant follicle-stimulating hormone [rFSH] [225 IU intramuscular [IM] from 2 to 10 day of MC [ = 32]), long GnRH agonist regimen (leuprolide from 21 day followed by leuprolide + rFSH from 2 to 10 day of MC [ = 19]), and antagonist regimen (human menopausal gonadotropin [hMG] [150 IU IM] from 2 day followed by hMG + cetrorelix from 7 to 10 day of MC) ( = 6) were recruited and followed up for follicular size, endometrial thickness, and pregnancy test. Data were analyzed using appropriate statistical test andP < 0.05 was considered statistically significant.

Results: A significant increase in follicular diameter and endometrial thickness was observed in patients treated with gonadotropin regimens as compared to CC alone ( < 0.0001). The highest number of positive pregnancy test with ultrasonographic evidence of gestational sac was observed with leuprolide + rFSH (long regimen) (10/19, 52.6%) followed by leuprolide + rFSH (short regimen) (13/32, 40.6%) while least in antagonist regimen (2/6, 33.3%) and CC (1/38, 2.63%). All regimens were well tolerated.

Conclusion: Treatment outcome was better with long agonist regimen.