AI Article Synopsis
- The study evaluated the effectiveness of the CSF T-SPOT.TB test for diagnosing TB meningitis (TBM) in 96 patients with meningitis.
- The test showed high diagnostic sensitivity (97.8%) and respectable specificity (78.0%), with positive predictive value (PPV) and negative predictive value (NPV) at 80.3% and 97.5%, respectively.
- The CSF T-SPOT.TB test demonstrated strong performance across different stages of TBM with an area under the curve (AUC) of 0.910, making it a reliable method for rapid and accurate diagnosis.
Article Abstract
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.
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| http://dx.doi.org/10.3967/bes2017.091 | DOI Listing |
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