AI Article Synopsis
- Toxocara canis is a significant zoonotic parasite affecting dogs, prompting a study to compare the effectiveness of two treatments: spinosad/milbemycin oxime and ivermectin/praziquantel.
- The study involved 200 naturally infected dogs, divided into two groups, receiving a single dose of either treatment, with stool samples collected at various intervals to assess the reduction of Toxocara eggs.
- Results showed that spinosad/milbemycin oxime resulted in a greater decrease in Toxocara spp. eggs and the number of infected dogs compared to ivermectin/praziquantel, demonstrating its higher efficacy.
Article Abstract
Toxocara canis is one of the most important zoonotic parasites of dogs. The aim of the present study was to compare the efficacy of spinosad/milbemycin oxime and ivermectin/praziquantel in dogs naturally infected with Toxocara spp. We studied 200 dogs with a positive diagnosis of Toxocara spp. Through coproparasitoscopic analysis, two study groups of 100 dogs each were assigned: spinosad/milbemycin oxime at a dose of 30-60mg/kg and 0.75-1.0mg/kg, respectively, or ivermectin/praziquantel administered at a dose of 0.2mg/kg and 5mg/kg, respectively. Both groups received a single dose. Three stool samples, one at day 0 before treatment, and at 14 and 28days post-treatment were examined using concentration-flotation techniques. In both treatments, the number of Toxocara spp. eggs decreased; with spinosad/milbemycin oxime treatment, eggs decreased by 87% at 14days (P=0.008) and 94% at 28days after treatment, compared with 71% at day 14 and 88% at day 28 in dogs medicated with ivermectin/praziquantel. The spinosad/milbemycin oxime treated group showed a greater decrease in the number of Toxocara spp. positive dogs compared to the group receiving ivermectin/praziquantel.
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| http://dx.doi.org/10.1016/j.vetpar.2017.09.016 | DOI Listing |
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