Background: One of the concerns associated with nonoperative management of splenic injury in children has been delayed splenic bleed (DSB) after a period of hemostasis. This study evaluates the incidence of DSB from a multicenter 3-year prospective study of blunt splenic injuries (BSI).

Methods: A 3-year prospective study was done to evaluate nonoperative management of pediatric (≤18years) BSI presenting to one of 10 pediatric trauma centers. Patients were tracked at 14 and 60days. Descriptive statistics were used to summarize patient and injury characteristics.

Results: During the study period, 508 children presented with BSI. Median age was 11.6 [IQR: 7.0, 14.8]; median splenic injury grade was 3 [IQR: 2, 4]. Nonoperative management was successful in 466 (92%) with 18 (3.5%) patients undergoing splenectomy at the index admission, all within 3h of injury. No patient developed a delayed splenic bleed. At least one follow-up visit was available for 372 (73%) patients.

Conclusion: A prior single institution study suggested that the incidence of DSB was 0.33%. Based on our results, we believe that the rate may be less than 0.2%.

Level Of Evidence: Level II, Prognosis.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpedsurg.2017.10.005DOI Listing

Publication Analysis

Top Keywords

delayed splenic
12
nonoperative management
12
splenic injury
8
splenic bleed
8
incidence dsb
8
3-year prospective
8
prospective study
8
splenic
6
study
5
incidence delayed
4

Similar Publications

Background: Generalized lymphatic anomaly (GLA) is a rare congenital lymphatic malformation (LM) characterized by multiple infiltrating lymphangiomas in various tissues. Owing to its rarity, information on this disease is obtained mainly through case reports, leading to delayed diagnosis. In this study, we reported a case of generalized lymphatic anomaly in a pediatric patient manifesting as hemorrhagic pleural effusion.

View Article and Find Full Text PDF

Background: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform management.

Objectives: To describe the disease burden of AAE-C1-INH, long-term prophylaxis (LTP) and the clinical, immunochemical and treatment profiles of AAE-associated diseases in UK.

View Article and Find Full Text PDF

Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner.

Neuroimage

January 2025

Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

Article Synopsis
  • Sepsis leads to systemic immune issues and organ failure, often resulting in severe brain disability, with young females showing better recovery than males.
  • Using a mouse model, researchers found that after experiencing sepsis, both male and female mice showed weight regain and reduced gut microbiome diversity, but males displayed more significant immune changes and brain inflammation.
  • fMRI analysis highlighted that while both sexes experienced similar changes in certain brain areas, male mice had altered connectivity patterns suggesting a delayed recovery process compared to females, indicating a complex, sex-dependent response to sepsis.
View Article and Find Full Text PDF

Introduction: MRTX1133 is a selective and reversible small molecule inhibitor of KRAS (G12D), which significantly delays the progression of solid tumors. However, no study on the absorption, distribution, and excretion of MRTX1133.

Methods: A fast ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry method was developed for the determination of MRTX1133 in rat plasma, tissue homogenate, and urine.

View Article and Find Full Text PDF

Curcumin reverses high-level tigecycline resistance mediated by different mechanisms in Gram-negative bacteria.

Phytomedicine

December 2024

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan Province, PR China; Henan Province Key Laboratory of Animal Food Pathogens SurveillancePR China. Electronic address:

Background: Tigecycline is one of the few effective treatments for multidrug-resistant bacteria. However, the recent emergence and spread of high-level tigecycline resistance in Enterobacteriaceae have significantly limited its clinical use. To combat this challenge, combining antibiotics with adjuvants has emerged as a promising strategy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!