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Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000-20: a retrospective analysis.
Lancet
January 2025
Centre for Health System Sustainability, School of Public Health, Brown University, Providence, RI, USA.
Background: Health systems experience difficult trade-offs when paying for new drugs. In England, funding recommendations by the National Institute for Health and Care Excellence (NICE) for new drugs might generate health gains, but inevitably result in forgone health as the funds cannot be used for alternative treatments and services. We aimed to evaluate the population-health impact of NICE recommendations for new drugs during 2000-20.
View Article and Find Full Text PDFManagement of Transanal Recto-Anal Foreign Body in a School-Aged Child: A Report of a Rare Case.
Cureus
November 2024
Gastroenterological Surgery, Nippon Medical School, Tokyo, JPN.
Transrectal recto-anal foreign bodies are occasionally encountered in routine practice, with sexual experimentation as the most common motivation for insertion. Although most patients with recto-anal foreign bodies are middle-aged, reports in younger patients are rare. In the present study, we encountered a case of recto-anal foreign body in a school-aged child.
View Article and Find Full Text PDFForage, freedom of movement, and social interactions remain essential fundamentals for the welfare of high-level sport horses.
Front Vet Sci
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INRAE, CNRS, Université de Tours, PRC, Nouzilly, France.
Article Synopsis
- Societal concerns about animal welfare now include high-level sport horses, especially highlighted during recent Olympics, leading to public inquiries about their living conditions.
- Animal welfare studies emphasize the "3Fs" for equine welfare: access to forage, freedom of movement, and social interactions, but the challenges for sport horses in meeting these needs are not well understood.
- A field study assessing 56 high-level sport horses found significant variability in access to the "3Fs," showing that those with fewer restrictions had better welfare outcomes.
The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains.
bioRxiv
November 2024
Laboratory of Addiction Genetics, Center for Drug Discovery, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA USA.
Concomitant with the opioid epidemic, there has been a rise in pregnant women diagnosed with opioid use disorder and cases of infants born with neonatal opioid withdrawal syndrome (NOWS). NOWS refers to signs and symptoms following cessation of prenatal opioid exposure that comprise neurological, gastrointestinal, and autonomic system dysfunction. A critical indicator of NOWS severity is excessive, high-pitched crying.
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Clin Microbiol Rev
December 2024
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
SUMMARYThe opportunistic pathogen (Mab) causes fatal lung infections that bear similarities-and notable differences-with tuberculosis (TB) pulmonary disease. In contrast to TB, no antibiotic is formally approved to treat Mab disease, there is no reliable cure, and the discovery and development pipeline is incredibly thin. Here, we discuss the factors behind the unsatisfactory cure rates of Mab disease, namely intrinsic resistance and persistence of the pathogen, and the use of underperforming, often parenteral and toxic, repurposed drugs.
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