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Evaluation and Management of Congenital Bleeding Disorders. | LitMetric

Evaluation and Management of Congenital Bleeding Disorders.

Hematol Oncol Clin North Am

Department of Emergency Medicine, Georgetown University Hospital/Washington Hospital Center, 110 Irving Street Northwest, Washington, DC 20010, USA.

Published: December 2017

AI Article Synopsis

  • Patients with clotting or platelet disorders who experience acute bleeding in the emergency department require careful evaluation due to the complexity of their condition.
  • The severity of bleeding is influenced by the patient's factor levels, with those having levels above 5% typically able to manage minor bleeding, while levels below 1% can lead to significant bleeding even from minor injuries.
  • Treatment should involve coordination with a hematologist, focusing on medications and specific factor replacement, although urgent situations may necessitate alternative options like cryoprecipitate or activated prothrombin complex.

Article Abstract

Patients presenting to the emergency department with acute bleeding and a history of clotting or platelet disorder present a unique challenge to the emergency physician. The severity of bleeding presentation is based on mechanism as well as factor levels: patients with factor levels greater than 5% can respond to most minor hemostatic challenges, whereas those with factor levels less than 1% bleed with minor trauma or even spontaneously. Treatment should be initiated in consultation with the patient's hematologist using medications and specific factor replacement, except in rare, life-threatening, resource-poor situations, when cryoprecipitate or activated prothrombin complex may be considerations.

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Source
http://dx.doi.org/10.1016/j.hoc.2017.08.011DOI Listing

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