AI Article Synopsis
- The Myc oncogene acts as a transcription factor that significantly influences cell growth and proliferation.
- Researchers have studied how Myc interacts with the E-box DNA motif, but it's unclear if this interaction alone is enough for Myc to attach to its target genes.
- The PAF1 complex, particularly the Leo1 component, has been identified as a crucial factor that assists in recruiting Myc to active genes, thereby helping it engage with open promoters.
Article Abstract
The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc's binding to its transcriptional targets. Here we identify the PAF1 complex, and specifically its component Leo1, as a factor that helps recruit Myc to target genes. Since the PAF1 complex is typically associated with active genes, this interaction with Leo1 contributes to Myc targeting to open promoters.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676885 | PMC |
| http://dx.doi.org/10.1073/pnas.1705816114 | DOI Listing |
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