In this Letter we give experimental grounding for the remarkable observation made by Furuberg et al. [Phys. Rev. Lett. 61, 2117 (1988)PRLTAO0031-900710.1103/PhysRevLett.61.2117] of an unusual dynamic scaling for the pair correlation function N(r,t) during the slow drainage of a porous medium. Those authors use an invasion percolation algorithm to show numerically that the probability of invasion of a pore at a distance r away and after a time t from the invasion of another pore scales as N(r,t)∝r^{-1}f(r^{D}/t), where D is the fractal dimension of the invading cluster and the function f(u)∝u^{1.4}, for u≪1 and f(u)∝u^{-0.6}, for u≫1. Our experimental setup allows us to have full access to the spatiotemporal evolution of the invasion, which is used to directly verify this scaling. Additionally, we connect two important theoretical contributions from the literature to explain the functional dependency of N(r,t) and the scaling exponent for the short-time regime (t≪r^{D}). A new theoretical argument is developed to explain the long-time regime exponent (t≫r^{D}).
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http://dx.doi.org/10.1103/PhysRevLett.119.154503 | DOI Listing |
BMC Public Health
January 2025
Statistics, Brigham Young University, Provo, 84602, Utah, USA.
Background: Bullying, encompassing physical, psychological, social, or educational harm, affects approximately 1 in 20 United States teens aged 12-18. The prevalence and impact of bullying, including online bullying, necessitate a deeper understanding of risk and protective factors to enhance prevention efforts. This study investigated the key risk and protective factors most highly associated with adolescent bullying victimization.
View Article and Find Full Text PDFRegulation of gene expression helps determine various phenotypes in most cellular life forms. It is orchestrated at different levels and at the point of transcription initiation by transcription factors (TFs). TFs bind to DNA through domains that are evolutionarily related, by shared membership of the same superfamilies (TF-SFs), to those found in other nucleic acid binding and protein-binding functions (nTFs for non-TFs).
View Article and Find Full Text PDFWorld Neurosurg
January 2025
Department of Rehabilitation, Lu 'an Hospital of Traditional Chinese Medicine of Anhui Province, Lu' an, Anhui, China. Electronic address:
Background: This study analyzes the factors influencing the 90-day prognosis of acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT) and established a multidimensional risk model to predict postoperative 90-day outcomes.
Methods: A retrospective analysis of clinical data was conducted for AIS patients who underwent MT at our hospital. A total of 111 patients who met the inclusion criteria were included in the study.
Biochim Biophys Acta Mol Basis Dis
January 2025
MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, Department of Bioinformatics and Computational Biology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, China; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China; Key Laboratory of Alkene-carbon Fibres-based Technology & Application for Detection of Major Infectious Diseases, Soochow University, Suzhou 215123, China; Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China. Electronic address:
Cancer, a heterogeneous disease, presents significant challenges for drug development due to its complex etiology. Drug repurposing, particularly through network medicine approaches, offers a promising avenue for cancer treatment by analyzing how drugs influence cellular networks on a systemic scale. The advent of large-scale proteomics data provides new opportunities to elucidate regulatory mechanisms specific to cancer subtypes.
View Article and Find Full Text PDFCells Dev
January 2025
Quantitative and Imaging Biology, International Research Collaboration Center (IRCC), National Institutes of Natural Sciences (NINS), Japan; Trans-Scale Biology Center, National Institute for Basic Biology (NIBB), National Institutes of Natural Sciences (NINS), Japan. Electronic address:
Collective cell migration is a fundamental process underlying various biological phenomena, including embryonic development and cancer cell invasion. The cohesive yet flexible movement of cell collectives largely depends on the coordinated regulation of cell-cell and cell-substrate adhesions. In this review, we summarize the regulation of key cell-cell junction components, such as cadherins and zonula occludens proteins during collective cell migration, with a particular focus on the recently discovered multifaceted roles of ZO-1 in both cell-cell and cell-substrate interactions.
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