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Chain-length-specific anti-Candida activity of cationic lipo-oxazoles: a new class of quaternary ammonium compounds. | LitMetric

AI Article Synopsis

  • Candida species are becoming resistant to standard antifungal drugs, prompting the exploration of quaternary ammonium compounds (QACs) as alternative treatments.
  • Researchers synthesized medium alkyl chain lipo-oxazoles and found that certain analogues (especially 5c) displayed strong anti-fungal properties against both sensitive and resistant strains of Candida.
  • The study concluded that these new QACs could effectively inhibit Candida cell adhesion and biofilm formation while also causing noticeable damage to the cell membrane.

Article Abstract

Purpose: Candida species have become resistant to commonly used anti-fungal drugs like fluconazole and echinocandins. In our screen, a series of quaternary ammonium compounds (QACs) emerged as an alternative treatment choice for drug-resistant Candida infections.

Methodology: Medium alkyl chain cationic lipo-oxazoles comprising six to thirteen twin carbon chains and a quaternary ammonium unit were synthesized and evaluated for their in vitro anti-Candida and biofilm inhibition activity. SEM was performed to visualize membrane distortion.Results/Key findings. Heptyl and octyl chain analogues (5c, 6b and 6c) showed promising anti-fungal activity. Compound 5c was active against both fluconazole-sensitive and resistant clinical isolates of Candida albicans as well as non-albicans Candida strains. 5c also inhibited the adhesion of C. albicans cells to a polystyrene surface and restricted biofilm formation. SEM further confirmed Candida cell membrane distortion by 5c.

Conclusion: A novel class of QACs, called cationic lipo-oxazoles, was tested and found to exhibit anti-fungal activity against planktonic cells as well as biofilms of Candida.

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Source
http://dx.doi.org/10.1099/jmm.0.000610DOI Listing

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