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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment.
Pharmaceutics
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, Iran.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body's organs, tissues, and cells that can be selectively transported to specific regions.
View Article and Find Full Text PDFTherapeutic Potential of (L.) . Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease.
Pharmaceuticals (Basel)
January 2025
School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, No. 58 Renmin Avenue, Haikou 570228, China.
Inflammatory bowel disease (IBD) is a persistent inflammatory condition affecting the gastrointestinal tract, distinguished by the impairment of the intestinal epithelial barrier, dysregulation of the gut microbiota, and abnormal immune responses. (L.) , traditionally used in Chinese herbal medicine for gastrointestinal issues such as bleeding and dysentery, has garnered attention for its potential therapeutic benefits.
View Article and Find Full Text PDFUtilizing Invasive as a Sustainable Fish Meal Substitute and Extract Supplement: Effects on Growth Performance, Organosomatic Indices, Hematological Profiles, and Serum Biochemistry in Chinese Bullfrogs ().
Life (Basel)
January 2025
Unit of Excellence Physiology and Sustainable Production of Terrestrial and Aquatic Animals, School of Agriculture and Natural Resources, University of Phayao, Phayao 56000, Thailand.
This research examined the efficacy of substituting commercial fish meal (CFM) with meal (PPM) in diets, with and without extract (EHE) supplementation. The study utilized six dietary treatments: a control diet (0% PPM, no EHE) and five experimental diets with varying PPM levels (0%+, 25%+, 50%+, 75%+, and 100%+), each fortified with 300 mg/kg EHE. The experiment spanned 90 days.
View Article and Find Full Text PDFMorphological Comparisons of Adult Worker Bees Developed in Chinese and Italian Honey Bee Combs.
Insects
January 2025
Yunnan Provincial Engineering and Research Center for Sustainable Utilization of Honey Bee Resources, Eastern Bee Research Institute, College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
The size of comb cells is a key factor influencing the body size of honey bee workers. Comb cells and the body size of Chinese honey bee workers are smaller than those of Italian honey bee workers. To increase the size of Chinese honey bee workers, this study used newly built combs from Chinese honey bee colonies (control group) and Italian honey bee colonies (treatment group).
View Article and Find Full Text PDFLethal Male Combat of (Hymenoptera: Eupelmidae), an Egg Parasitoid of Lepidopterous and Hemipterous Pests.
Insects
January 2025
MARA-CABI Joint Laboratory for Bio-Safety, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Aggressive interactions between males are common when victors gain increased mating success but can result in severe injury or death for the defeated. (Hymenoptera: Eupelmidae) is a solitary egg parasitoid of hemipteran and lepidopteran species. Here, we investigated lethal interactions between males and analyzed aggression behavior scaled with the male condition, number of competitors, number of presented females, and female mating status.
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