Background: Intrauterine hematomas are a common pregnancy complication. The literature lacks studies about outcomes based on hematoma localization. Thus, we aimed to compare pregnancies complicated by an intraplacental hematoma to cases with a retroplacental hematoma and to a control group.
Methods: In a retrospective case-control study, 32 women with an intraplacental hematoma, 199 women with a retroplacental hematoma, and a control group consisting of 113 age-matched women with no signs of placental abnormalities were included. Main outcome measures were pregnancy complications.
Results: Second-trimester miscarriage was most common in the intraplacental hematoma group (9.4%), followed by women with a retroplacental hematoma (4.2%), and controls (0%; p = 0.007). The intraplacental hematoma group revealed the highest rates for placental insufficiency, intrauterine growth retardation, premature preterm rupture of membranes, preterm labor, preterm delivery <37 weeks, and early preterm delivery <34 weeks (p < 0.05), followed by the retroplacental hematoma group. When tested in multivariate models, intraplacental hematomas were independent predictors for placental insufficiency (ß = 4.19, p < 0.001) and intrauterine growth restriction (ß = 1.44, p = 0.035). Intrauterine fetal deaths occurred only in women with a retroplacental hematoma (p = 0.042).
Conclusions: Intra- and retroplacental hematomas have different risk profiles for the affected pregnancy and act as independent risk factors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658933 | PMC |
| http://dx.doi.org/10.1186/s12884-017-1539-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
BIOCHEMICAL MARKERS OF MISCARRIAGE ASSOCIATED WITH THE INTRAPLACENTAL ACCUMULATION OF 137Cs.
Probl Radiac Med Radiobiol
December 2024
State Institution «Ukrainian Сenter of Maternity and Childhood of the National Аcademy of Мedical Sciences of Ukraine», 8 Platona Mayborody Str., Kyiv, 04050, Ukraine.
Unlabelled: The impact of the environment on human health in modern conditions cannot be underestimated. The study of thepathogenesis of disease is impossible without establishing the factors of destabilization of biological membranes.The article highlighted the problem of lipid peroxidation and antioxidant defense associated with the accumulationof radiocesium in the placenta.
View Article and Find Full Text PDFMagnetic Resonance Imaging Findings of Placenta Accreta Spectrum Disorder: A Pictorial Review.
Top Magn Reson Imaging
December 2024
Department of Radiology, La Rabta Hospital of Tunis, University of Medicine of Tunis, Tunis, Tunisia; and.
Magnetic resonance imaging (MRI) is used for diagnosing placenta accreta spectrum disorders (PASDs) because of its advanced soft-tissue contrast and spatial resolution capabilities, offering better contrast, improved spatial resolution, and a wider field of view compared with ultrasound. Using a 1.5-Tesla MRI protocol with multiple sequences, MRI can detect indicative signs of PASD such as placental signal heterogeneity, interruption of the myometrium-placenta interface, and abnormal vascularization.
View Article and Find Full Text PDFMassive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: Case Report and Review of the Literature.
Diagnostics (Basel)
November 2024
Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, 71121 Foggia, Italy.
Intraplacental choriocarcinoma (IC) is a gestational trophoblastic neoplasia located within the placenta. Due to its silent presentation, more than half of the cases are diagnosed incidentally. An association with fetomaternal hemorrhage (FMH), stillbirth, and intrauterine growth restriction has been found.
View Article and Find Full Text PDFPlacental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1.
Mol Hum Reprod
November 2024
Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Currently, there are no placenta-targeted treatments to alter the in utero environment for administration to pregnant women who receive a diagnosis of fetal growth restriction (FGR). Water-soluble polymers have a distinguished record of clinical relevance outside of pregnancy. We have demonstrated the effective delivery of polymer-based nanoparticles containing a non-viral human insulin-like growth factor 1 (IGF1) transgene to correct placental insufficiency in small animal models of FGR.
View Article and Find Full Text PDFNanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque.
Placenta
September 2024
Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA; Center for Research in Perinatal Outcomes, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:
Nanoparticles offer promise as a mechanism to non-invasively deliver targeted placental therapeutics. Our previous studies utilizing intraplacental administration demonstrate efficient nanoparticle uptake into placental trophoblast cells and overexpression of human IGF1 (hIGF1). Nanoparticle-mediated placental overexpression of hIGF1 in small animal models of placental insufficiency and fetal growth restriction improved nutrient transport and restored fetal growth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!