Juvenile pityriasis rubra pilaris: successful treatment with methotrexate.

Clin Exp Dermatol

Departments of Dermatology and Allergology, University Hospital of RWTH Aachen, Aachen, Germany.

Published: January 2018

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http://dx.doi.org/10.1111/ced.13281	DOI Listing

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Skin Health Dis

August 2024

Pityriasis rubra pilaris (PRP) is a rare skin disease that looks a lot like psoriasis and affects the skin on the palms and soles.
Some recent treatments using special medicines called monoclonal antibodies have shown good results for people with PRP.
One case of an adult diagnosed with an unusual type of PRP showed major improvement after receiving a specific treatment and emphasized the importance of genetic testing in figuring out tricky skin diseases.

Pediatr Dermatol

November 2024

Harvard Medical School, Boston, Massachusetts, USA.

Juvenile pityriasis rubra pilaris is a rare inflammatory skin condition that currently lacks FDA-approved treatments and can be tough to manage with standard therapies.
A 6-year-old boy achieved clear skin within 2 weeks after starting ixekizumab therapy, which has remained effective for 6 months.
This case suggests ixekizumab could be a promising and quick treatment option for children suffering from this rare skin disorder.

Skin Appendage Disord

April 2024

Psoriasis is an autoimmune skin condition with many subtypes, including the lesser-known follicular psoriasis (FP), which presents as scaly bumps around hair follicles.
A case study of a 31-year-old male with symmetrically itchy, scaly lesions was diagnosed with FP after utilizing dermoscopy and histopathology, resulting in successful treatment.
The discussion highlights the rarity of FP, notes the potential role of immune cells and keratin 17 in its development, and calls for more research to better understand the condition and its diagnosis through dermoscopy.