Purpose: The study aims to assess the quality of life (QOL) of oral cancer survivors, 1-5 years after the treatment.
Materials And Methods: The data of fifty patients concerning their QOL were gained from the Outpatient Department of K.L.E's Dr. Prabhakar Kore Hospital and Medical Research Institute, Belagavi, and Karnataka Cancer Therapy and Research Institute, Navanagar, Hubli, Karnataka, India. All the patients suffered from oral cancer (stage T2-T4) and underwent surgery with reconstruction followed by chemotherapy or radiotherapy or both. The patients completed the standard European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) C-30 (version 3.0) and QLQ Head and Neck Cancer Specific (QLQ H and N-35) (version 1.0). Scoring was done according to the EORTC scoring manual.
Results: The mean age at the time of diagnosis was 45.0 (±9.0). The study population had a mean global health status (GHS) for overall QOL of 55.5 ± 13.4.The mean functional scale (FS) was 87.5 (±9.6).The mean QLQ C-30 symptom scale (SS) was 16.3 (±11.9) and the mean QLQ H and N-35 SS (H and NSS) was 26.9 ± 11.5. Location, gender, age, and time after the treatment showed very less discrepancy in the group comparisons of GHS, FS, SS, and H and NSS whereas comparison based on T-stage showed significant difference in scores.
Conclusion: Oral cancer has a significant impact on the QOL of the patients. Assessment of QOL should receive adequate attention in treatment planning and rehabilitation. This would definitely help in delivery of better symptom directed therapies and improve the QOL of the patients.
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http://dx.doi.org/10.4103/ijdr.IJDR_97_17 | DOI Listing |
Annu Rev Med
January 2025
Medical Oncology Department, Vall d'Hebron Barcelona Hospital Campus and Breast Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; email:
Oral selective estrogen receptor degraders (SERDs) are pure estrogen receptor antagonists that have the potential to overcome common resistance mechanisms to endocrine therapy in estrogen receptor-positive breast cancer. There are currently five oral SERDs in published and ongoing clinical trials-elacestrant, camizestrant, giredestrant, imlunestrant, and amcenestrant-with more in development. They offer a reasonably well-tolerated oral therapy option with low discontinuation rates in studies.
View Article and Find Full Text PDFInt J Surg
January 2025
Department of Geriatrics, Zhongshan Hospital Xiamen University, Fujian, People's Republic of China.
Introduction: What interventions effectively prevent postoperative stenosis following endoscopic resection (ER) of superficial esophageal cancer? This study aimed to identify effective interventions or combinations through a systematic review and network meta-analysis.
Methods: Six databases were systematically searched for eligible studies up to 30 April 2023, on interventions to prevent esophageal stenosis post-ER. Odds ratios (ORs) evaluated stenosis rate (primary outcome) and complications (secondary outcome), while mean differences (MD) evaluated endoscopic balloon dilatation (EBD) sessions post-stenosis.
Discov Oncol
January 2025
Department of Stomatology, Hangzhou Linping District First People's Hospital, Hangzhou, China.
Objectives: This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer.
Methods: This study investigated genetic variants that have been associated with oral and oropharyngeal cancer using data from a large GWAS. Inflammatory cytokine data were obtained from 8293 asymptomatic individuals.
Curr Opin Oncol
January 2025
DIOPP, Gustave Roussy Cancer Campus, Villejuif, France.
Purpose Of Review: Monitoring the side effects of treatments in cancer patients is a key challenge in clinical practice, especially with the development of oral therapies.The impact on patients is multifaceted: morbidity or even life-threatening risks in the case of severe side effects; deterioration in quality of life and functional abilities; lower adherence to treatments; reduced dose intensity, which can affect the efficacy of therapies.
Recent Findings: The availability of digital tools for remote patient monitoring is transforming our ability to track these patients effectively.
Curr Opin Oncol
January 2025
Gustave Roussy, Villejuif, France.
Purpose Of Review: Although the management of nausea and vomiting induced by cancer treatments has evolved, several questions remain unanswered.
Recent Findings: New antiemetics have been developed these last decades with therapeutic indications to be defined according to the anticancer regimen and partly as a consequence of the assessment of individual patient risk factors. Guidelines still seem to have a low level of knowledge and compliance, with a role for scientific societies in term of dissemination and education.
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