AI Article Synopsis
- This study aimed to determine the effective doses of 0.5% hypobaric bupivacaine and ropivacaine for unilateral spinal anesthesia in elderly patients (70+ years) undergoing hip replacement surgery.
- A total of 60 patients were randomized into two groups, receiving either bupivacaine or ropivacaine, with effective anesthesia defined by specific sensory and motor blockade criteria.
- Results indicated that the median effective dose for bupivacaine was 4.66 mg and for ropivacaine was 6.43 mg, both showing lower doses needed for effective anesthesia in this age group.
Article Abstract
Background: Unilateral spinal anesthesia (USpA) has been reported to potentiate spinal anaesthesia and is used in geriatric patients. The purpose of this study was to determine the median effective dose (ED) of 0.5% hypobaric bupivacaine and 0.5% hypobaric ropivacaine USpA for geriatric patients (age ≥ 70 years) undergoing elective hip replacement surgery.
Methods: A total of 60 geriatric patients (age ≥ 70 years) undergoing elective hip replacement surgery were enrolled in this study. The patients were randomized into 2 groups to receive either intrathecal 0.5% hypobaric bupivacaine USpA (group B) or 0.5% hypobaric ropivacaine USpA (group R). Effective anesthesia was defined as a T10 sensory blockade level maintained for more than 60 min, and a Bromage score of 3 on the operation side within 10 min after injection with no additional epidural anesthetic required during surgery. The ED of 0.5% hypobaric bupivacaine and 0.5% hypobaric ropivacaine was calculated using the Dixon and Massey formula.
Results: No significant differences were found between the two groups in terms of demographic data. The ED of 0.5% hypobaric bupivacaine USpA was 4.66 mg (95% confidence interval CI 4.69-4.63 mg) mg and that of 0.5% hypobaric ropivacaine USpA was 6.43 mg (95% CI 6.47-6.39 mg) for geriatric patients undergoing hip replacement surgery.
Conclusion: We find the ED were lower, and the ED50 of 0.5% hypobaric bupivacaine and ropivacaine was 4.66 mg (95% CI 4.69-4.63 mg) and 6.43 mg (95% CI 6.47-6.39 mg), respectively, for USpA in geriatric patients (age ≥ 70 years) undergoing elective hip replacement surgery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707229 | PMC |
| http://dx.doi.org/10.1007/s00101-017-0370-9 | DOI Listing |
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