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Neuroleptic-induced acute respiratory distress syndrome.
Sao Paulo Med J
May 2003
Division of Clinical Emergency, Department of Medicine, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Context: A case of neuroleptic malignant syndrome and acute respiratory distress syndrome is presented and discussed with emphasis on the role of muscle relaxation, creatine kinase, and respiratory function tests.
Case Report: A 41-year-old man presented right otalgia and peripheral facial paralysis. A computed tomography scan of the skull showed a hyperdense area, 2 cm in diameter, in the pathway of the anterior intercommunicating cerebral artery.
Inhibition of complex I by neuroleptics in normal human brain cortex parallels the extrapyramidal toxicity of neuroleptics.
Mol Cell Biochem
September 1997
Department of Neurology, Friedrich-Wilhelms-Universität, Bonn, Germany.
There is increasing evidence that a defect of the mitochondrial respiratory chain is implicated in the development of Parkinson disease. Decreased complex I activity of the mitochondrial respiratory chain has been reported in platelets, muscle, and brain of patients with Parkinson disease. Extrapyramidal symptoms (e.
View Article and Find Full Text PDFNeuroleptic-induced mitochondrial enzyme alterations in the rat brain.
J Pharmacol Exp Ther
January 1997
Department of Medical Pharmacology, Uppsala University, Sweden.
For years, it has been known that neuroleptics have the capacity to interfere with the mitochondrial respiratory chain in vitro. We report that haloperidol and fluphenazine, classical neuroleptics, cause a generalized reduction in the activity of NADH: ubiquinone oxidoreductase (complex I) in the rat brain in vivo, an effect that was not observed with the atypical neuroleptic, clozapine. MPTP, which bears significant structural similarities with haloperidol, also demonstrated a significant reduction in complex I activity after low-dose, chronic administration.
View Article and Find Full Text PDFNeuroleptic-induced respiratory dyskinesia.
J Neuropsychiatry Clin Neurosci
September 1995
Neuropsychiatric Institute, Prince Henry Hospital, Matraville, NSW, Australia.
Respiratory dyskinesia is a common but under-recognized side effect of chronic neuroleptic administration. It manifests as irregular respiration, dyspnea, grunting or gasping, and abnormal chest or esophageal movements. It occurs almost exclusively in association with other tardive effects of neuroleptics, such as tardive dyskinesia and tardive akathisia.
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