Objective: To study the therapeutic effect of rhSCF early administration on rhesus monkeys with severe acute radiation sickness(ARS).
Methods: Twelve adult monkeys totally exposed to 7.0 Gy Co were divided into radiation control and SCF groups, and monkeys in SCF group were subcutaneously injected recombinant human SCF(rhSCF) 200 µg/kg at half an hour and 24 hour after irradiation, while the radiation control monkeys were injected physiological saline. Survival was monitored and hematopoiesis was evaluated at 40 days following early treatment.
Results: 6 animals treated with rhSCF all survived, while 2 in irradiated controls survived on 40 day after radiation. rhSCF treatment promoted hematopoiesis recovery significantly, increased the nadir of white blood cells, neutrophils and platelets, and simplified supportive care in ARS rhesus monkeys.
Conclusion: RhSCF injection soon after TBI taken shows an significant therapeutic efficiency on rhesus monkeys with severe acute radiation sickness.
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| http://dx.doi.org/10.7534/j.issn.1009-2137.2017.05.047 | DOI Listing |
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