AI Article Synopsis
- The study aimed to assess ACE activity in dogs, focusing on those with and without a genetic variation (polymorphism) in the ACE gene, both before and after ACE inhibitor treatment.
- Thirty-one dogs with heart disease were included, with measurements of ACE activity and blood pressure taken before and after administering enalapril, an ACE inhibitor.
- Results showed that dogs with the ACE polymorphism had lower ACE activity before treatment but responded similarly to the ACE inhibitor as wild-type dogs, indicating the genetic variant influences ACE levels but not the inhibitor's effectiveness.
Article Abstract
Objective: The objective of this study was to evaluate angiotensin-converting enzyme (ACE) activity in dogs and with and without an ACE polymorphism in the canine ACE gene, before and after treatment with an ACE inhibitor.
Methods: Thirty-one dogs (20 wild-type, 11 ACE polymorphism) with heart disease were evaluated with ACE activity measurement and systolic blood pressure before and after administration of an ACE inhibitor (enalapril).
Results: Median pre-treatment ACE activity was significantly lower for ACE polymorphism dogs than for dogs with the wild-type sequence ( P=0.007). After two weeks of an ACE inhibitor, ACE activity was significantly reduced for both genotypes (wild-type, P<0.0001; ACE polymorphism P=0.03); mean post-therapy ACE activity was no different between the groups.
Conclusion: An ACE polymorphism is associated with lower levels of ACE activity. Dogs with the polymorphism still experience suppression of ACE activity in response to an ACE inhibitor. It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843865 | PMC |
| http://dx.doi.org/10.1177/1470320317737184 | DOI Listing |
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