Association between gene polymorphisms and IgA nephropathy risk in a Chinese Han population.

Multiple genetic and environmental factors together contribute to the risk of IgA nephropathy (IgAN). play an important role in the recruitment of the exosome to the pre-rRNA. However, to date, little information is found about the association between polymorphisms and the IgAN risk. In this case-control study, we genotyped five single nucleotide polymorphisms (SNPs) in gene in 416 IgAN cases and 495 controls using Sequenom Mass-ARRAY technology and evaluated their association with IgAN using the χ2 and genetic model analysis. In the allelic model analysis, we determined rs1056654 was associated with a 0.774-fold decrease in the risk of IgAN (95%CI= 0.630-0.952; = 0.015). In the genetic model analysis, we found that the "C/C" genotype of rs1056675 was associated with an increased risk of IgAN based on the codominant model (OR =1.48; 95% CI=1.03-2.13; =0.033) and recessive model (OR =1.52; 95% CI=1.11-2.09; =0.0095). The "G/A-A/A" genotype of rs1056654 was associated with a decreased risk of IgAN based on the dominant model (OR =0.75; 95% CI=0.58-0.98; =0.032) and log-additvie model (OR =0.78; 95% CI=0.64-0.96; =0.0188). Our data suggested that gene polymorphisms in the may exert influences IgAN susceptibility in a Chinese Han population.