A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: Network is unreachable

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

MoS/Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells. | LitMetric

This work describes the adaptive use of a conventional stainless steel acupuncture needle as the electrode substrate for construction of a molybdenum disulfide (MoS) and platinum nanoparticles (PtNPs) layer-modified microneedle sensor for real-time monitoring of hydrogen peroxide (HO) release from living cells. To construct the nanocomposite-functionalized microneedle, the needle surface was first coated with a gold film by ion sputtering to enhance the conductivity. Subsequently, an electrochemical deposition method was successfully employed to deposit MoS nanosheet and Pt nanoparticles on the needle tip as the sensing interface. Electrochemical study demonstrated that the MoS/PtNPs nanocomposite-modified needle exhibited excellent catalytic performance and low over-potential toward the reduction of HO. Not only did the microneedle achieve a wide linear range from 1 to 100 μmol L with a limit of detection down to 0.686 μmol L, but it also realized the highly specific detection of HO. Owing to these remarkable analytical advantages, the prepared microneedle was applied to determine HO release from living cells with satisfactory results. The MoS/PtNPs nanocomposite-functionalized microneedle sensor is simple and affordable, and can serve as a promising electrochemical nonenzymatic sensing platform. Moreover, this superfine needle sensor shows great potential for real-time monitoring of reactive oxygen species in vivo with minimal damage.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7an01446eDOI Listing

Publication Analysis

Top Keywords

nanocomposite-functionalized microneedle
12
real-time monitoring
12
release living
12
living cells
12
monitoring hydrogen
8
hydrogen peroxide
8
peroxide release
8
microneedle sensor
8
microneedle
6
needle
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!