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Combination of interleukin-10 gene promoter polymorphisms with HLA-DRB1*15 allele is associated with multiple sclerosis. | LitMetric

AI Article Synopsis

  • Multiple sclerosis (MS) is influenced by genetic factors, particularly the IL-10 cytokine and HLA-DRB1*15 allele variations, which may affect disease susceptibility in certain ethnic groups, including Iranians.
  • A study involving 336 MS patients and 454 healthy controls was conducted to analyze the relationship between IL-10 gene promoter polymorphisms and HLA-DRB1*15 allele frequencies.
  • Results showed that specific IL-10 genotypes were more prevalent in MS patients, suggesting that these genetic variations play a significant role in the risk of developing MS among the population studied.

Article Abstract

Background & Objectives: Multiple sclerosis (MS) is common in some ethnic groups. Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine that may be an important regulator in MS disease pathogenesis. IL-10 promoter includes several single nucleotide polymorphisms and the level of IL-10 expression is related to these polymorphisms. Furthermore, loci within the histocompatibility regions are responsible for susceptibility to MS. The aim of this study was to investigate the association of IL-10 gene promoter polymorphisms and HLA-DRB1*15 allele frequencies with MS susceptibility in an Iranian population.

Methods: In this study 336 MS patients and 454 healthy controls were included. Genomic DNA was purified from peripheral blood samples by a standard protocol. Genotyping was performed by the sequence-specific primer polymerase chain reaction method.

Results: IL-10 -1082 G/G and IL-10 -819 C/C genotypes were more frequent in MS patients than healthy individuals. DRB1*15 allele showed a higher frequency among MS patients compared to controls.

Interpretation & Conclusions: The IL-10 and HLA-DRB1*15 polymorphisms were associated with the susceptibility to MS in Iranian patients. Our results suggest that gene-gene interaction of IL-10 polymorphisms and HLA-DRB1*15 alleles may be important factors in the development of MS.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674544PMC
http://dx.doi.org/10.4103/ijmr.IJMR_1225_15DOI Listing

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