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Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD). Following the conjunction of ferulic acid (FA)/gallic acid (GA) with sulfonamide, alanine and 2-aminobenzothiazole, we planned to assess the radical scavenging and antioxidant properties of synthesized analogs by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric ion reducing antioxidant power (FRAP) assays. GA analog 28 was identified as the most potent antioxidant compound with IC values of 1.
View Article and Find Full Text PDFIdentification and Characterization of Neuroprotective Properties of Thaumatin-like Protein 1a from Apple Flesh Polyphenol Extract.
Nutrients
January 2024
Department of Medical, Movement and Well-Being Sciences (DiSMMeB), University of Naples "Parthenope", Via Medina 40, 80133 Napoli, Italy.
Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (AChE, BuChE) or monoamine oxidases (MAO)-A/B, and of A aggregation. Diet plant components with multitarget functions are promising compounds in the prevention of AD and PD. Our aim was to identify neuroprotective compounds from apple polyphenol extract (AFPE).
View Article and Find Full Text PDFEffect of aminergic signaling on the humoral innate immunity response of .
Front Physiol
August 2023
Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy.
Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed whether the aminergic neurotransmission of dopamine, serotonin, and octopamine could have an impact on the humoral innate immune response of .
View Article and Find Full Text PDFInhibition of Enzymes Involved in Neurodegenerative Disorders and A Aggregation by Peel Polyphenol Extract.
Molecules
August 2023
Dipartimento di Scienze Motorie e del Benessere, Università degli Studi di Napoli "Parthenope", Via Medina, 40, 80133 Napoli, Italy.
Alzheimer's (AD) and Parkinson's diseases (PD) are multifactorial neurogenerative disorders of the Central Nervous System causing severe cognitive and motor deficits in elderly people. Because treatment of AD and PD by synthetic drugs alleviates the symptoms often inducing side effects, many studies have aimed to find neuroprotective properties of diet polyphenols, compounds known to act on different cell signaling pathways. In this article, we analyzed the effect of polyphenols obtained from the agro-food industry waste of peel (LPE) on key enzymes of cholinergic and aminergic neurotransmission, such as butyryl cholinesterase (BuChE) and monoamine oxidases (MAO)-A/B, on A aggregation and on superoxide dismutase (SOD) 1/2 that affect oxidative stress.
View Article and Find Full Text PDFThe Geomagnetic Field (GMF) Is Necessary for Black Garden Ant ( L.) Foraging and Modulates Orientation Potentially through Aminergic Regulation and Expression.
Int J Mol Sci
February 2023
Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13/Via Gioacchino Quarello 15/A, 10123 Torino, Italy.
The geomagnetic field (GMF) can affect a wide range of animal behaviors in various habitats, primarily providing orientation cues for homing or migratory events. Foraging patterns, such as those implemented by , are excellent models to delve into the effects of GMF on orientation abilities. In this work, we assessed the role of GMF by comparing the foraging and orientation performance, brain biogenic amine (BA) contents, and the expression of genes related to the magnetosensory complex and reactive oxygen species (ROS) of workers exposed to near-null magnetic fields (NNMF, ~40 nT) and GMF (~42 µT).
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