AI Article Synopsis

  • Increased vascularity is a key feature of renal cell carcinoma (RCC), and this study explores the relationship between microvessel density (MVD) and patient outcomes in high-risk RCC patients.
  • In a clinical trial with 1,943 participants, researchers analyzed tissue samples from 822 patients and found that high MVD is linked to longer overall survival (OS), particularly in those who received placebo treatment.
  • While MVD did not correlate with disease-free survival (DFS), it was independently associated with improved OS and showed connections to specific tumor characteristics, suggesting its potential as a prognostic biomarker in RCC outcomes.

Article Abstract

Increased vascularity is a hallmark of renal cell carcinoma (RCC). Microvessel density (MVD) is one measurement of tumor angiogenesis; however, its utility as a biomarker of outcome is unknown. ECOG-ACRIN 2805 (E2805) enrolled 1,943 resected high-risk RCC patients randomized to adjuvant sunitinib, sorafenib, or placebo. We aimed to determine the prognostic and predictive role of MVD in RCC. We obtained pretreatment primary RCC nephrectomy tissues from 822 patients on E2805 and constructed tissue microarrays. Using quantitative immunofluorescence, we measured tumor MVD as the area of CD34-expressing cells. We determined the association with disease-free survival (DFS), overall survival (OS), treatment arm, and clinicopathologic variables. High MVD (above the median) was associated with prolonged OS for the entire cohort ( = 0.021) and for patients treated with placebo ( = 0.028). The association between high MVD and OS was weaker in patients treated with sunitinib or sorafenib ( = 0.060). MVD was not associated with DFS ( = 1.00). On multivariable analysis, MVD remained independently associated with improved OS ( = 0.013). High MVD correlated with Fuhrman grade 1-2 ( < 0.001), clear cell histology ( < 0.001), and absence of necrosis ( < 0.001) but not with gender, age, sarcomatoid features, lymphovascular invasion, or tumor size. High MVD in resected high-risk RCC patients is an independent prognostic, rather than predictive, biomarker of improved OS. Further studies should assess whether incorporating MVD into clinical models will enhance our ability to predict outcome and if low MVD can be used for selection of high-risk patients for adjuvant therapy trials. .

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904512PMC
http://dx.doi.org/10.1158/1078-0432.CCR-17-1555DOI Listing

Publication Analysis

Top Keywords

high mvd
16
patients treated
12
mvd
11
microvessel density
8
renal cell
8
cell carcinoma
8
resected high-risk
8
high-risk rcc
8
rcc patients
8
sunitinib sorafenib
8

Similar Publications

Indobufen-based Dual Antiplatelet Therapy in Patients with Multivessel Coronary Disease Undergoing Drug-eluting Stent Implantation Insight From the OPTION Trial.

Am Heart J

December 2024

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai, China; Department of Cardiology, Shanghai Geriatric Medical Center, Shanghai, China. Electronic address:

Background: It remains unclear whether indobufen-based dual antiplatelet therapy (DAPT) preserves ischemic protection while limiting bleeding risk in patients with multivessel coronary disease (MVD). This study aimed to investigate the efficacy and safety of indobufen-based DAPT in patients with MVD.

Methods: Patients in the OPTION trial were stratified based on the presence of MVD.

View Article and Find Full Text PDF

Marburg Virus Reaches Rwanda: How Close Are We to a Vaccine Solution?

Int J Infect Dis

December 2024

Department of General Medicine and Surgery, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. Electronic address:

Marburg virus disease (MVD) is a highly virulent and often fatal disease caused by the Marburg virus, a member of the Filoviridae family, closely related to the Ebola virus. Historically, outbreaks have been sporadic but lethal across various African countries, with high case fatality rates (CFRs). In 2023, significant outbreaks occurred in Tanzania and Equatorial Guinea, with CFRs of 62.

View Article and Find Full Text PDF

Background: Marburg virus disease (MVD) is categorized among viral hemorrhagic fevers. MVD is associated with high rates of morbidity and mortality. This study aimed to identify factors affecting MVD knowledge, attitudes and practices in sub-Saharan African countries.

View Article and Find Full Text PDF

The reference electrode's performance is essential for ensuring the accuracy of electrochemical sensors in marine environments. Yet, the many existing reference electrodes can exhibit sensitivity to salinity variations, potentially leading to inaccuracies in the measurement process. Herein, we have designed a reliable solid-state reference electrode by introducing SiO-stabilized 1-methyl-3-octylimidazolium bis(trifluoromethyl sulfonyl)imide ([Cmim] [Ntf]) into a P(VdF--HFP) matrix with a SPEEK/[Cmim] [Ntf] coated Ag/AgCl as substrate.

View Article and Find Full Text PDF

Background & Objective: Hypervascularity is a characteristic feature of renal cell carcinoma (RCC) and microvessel density (MVD) predicts tumor metastasis. Nestin is a stem cell marker that is expressed in proliferating endothelial cells and newly formed vessels and Fms-related tyrosine kinase 1 (FLT1) is a proangiogenic factor. This study aimed to evaluate the expression of Nestin and FLT1 in RCC and their prognostic impact.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: