AI Article Synopsis
- - A study involved 517 adults aged 50-84 to examine the effects of long-term high-dose vitamin D supplementation on central blood pressure, comparing a vitamin D group with a placebo group over roughly 1.1 years.
- - The vitamin D group showed a significant increase in vitamin D levels, with some positive changes in blood pressure measures specifically among participants who were vitamin D deficient at the start of the trial.
- - Overall, while vitamin D supplementation did not result in significant blood pressure changes in all participants, it did lead to notable improvements in central blood pressure parameters for those who were initially deficient in vitamin D.
Article Abstract
Background: The effects of monthly, high-dose, long-term (≥1-year) vitamin D supplementation on central blood pressure (BP) parameters are unknown.
Methods And Results: A total of 517 adults (58% male, aged 50-84 years) were recruited into a double-blinded, placebo-controlled trial substudy and randomized to receive, for 1.1 years (median; range: 0.9-1.5 years), either (1) vitamin D 200 000 IU (initial dose) followed 1 month later by monthly 100 000-IU doses (n=256) or (2) placebo monthly (n=261). At baseline (n=517) and follow-up (n=380), suprasystolic oscillometry was undertaken, yielding aortic BP waveforms and hemodynamic parameters. Mean deseasonalized 25-hydroxyvitamin D increased from 66 nmol/L (SD: 24) at baseline to 122 nmol/L (SD: 42) at follow-up in the vitamin D group, with no change in the placebo group. Despite small, nonsignificant changes in hemodynamic parameters in the total sample (primary outcome), we observed consistently favorable changes among the 150 participants with vitamin D deficiency (<50 nmol/L) at baseline. In this subgroup, mean changes in the vitamin D group (n=71) versus placebo group (n=79) were -5.3 mm Hg (95% confidence interval [CI], -11.8 to 1.3) for brachial systolic BP (=0.11), -2.8 mm Hg (95% CI, -6.2 to 0.7) for brachial diastolic BP (=0.12), -7.5 mm Hg (95% CI, -14.4 to -0.6) for aortic systolic BP (=0.03), -5.7 mm Hg (95% CI, -10.8 to -0.6) for augmentation index (=0.03), -0.3 m/s (95% CI, -0.6 to -0.1) for pulse wave velocity (=0.02), -8.6 mm Hg (95% CI, -15.4 to -1.9) for peak reservoir pressure (=0.01), and -3.6 mm Hg (95% CI, -6.3 to -0.8) for backward pressure amplitude (=0.01).
Conclusions: Monthly, high-dose, 1-year vitamin D supplementation lowered central BP parameters among adults with vitamin D deficiency but not in the total sample.
Clinical Trial Registration: URL: http://www.anzctr.org.au. Unique identifier: ACTRN12611000402943.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721873 | PMC |
| http://dx.doi.org/10.1161/JAHA.117.006802 | DOI Listing |
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