We evaluate the role of antioxidant enzyme status and inflammatory cascade in disease progression of cystitis in a rat model. The animals were injected with clinically isolated Uropathogenic Escherichia coli (UPEC) and study the effect of various antioxidant enzymes and inflammatory markers in disease pathology on the 0 day, 12 h and 7 day of infection. The antioxidant status of bladder tissue was decreased during the 7 day of infection. Lipid peroxidation marker MDA was increased on the 7 day of infection in rats. The histopathology of bladder tissue shows severe inflammation and edema. This study reveals the role of decreased antioxidant status during infection play a vital role in upregulation of inflammation and tissue destruction.
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| http://dx.doi.org/10.1016/j.micpath.2017.10.035 | DOI Listing |
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