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Removal of Arterial Vessel Contributions in Susceptibility-Weighted Images for Quantification of Normalized Visible Venous Volume in Children with Sickle Cell Disease. | LitMetric

AI Article Synopsis

  • A study evaluated a new method to accurately measure normalized visible venous volume (NVVV) by removing the influence of arterial vessel signals in susceptibility-weighted imaging (SWI) for children with sickle cell disease (SCD).
  • The researchers found that 86% of SWI exams were affected by arterial signal contamination, which led to an overestimation of NVVV by about 33%.
  • The proposed method successfully corrected this contamination, and further research is required to confirm its effectiveness and explore NVVV's potential as a biomarker for SCD severity and stroke risk.

Article Abstract

Purpose: To evaluate a new postprocessing framework that eliminates arterial vessel signal contributions in the quantification of normalized visible venous volume (NVVV, a ratio between venous and brain volume) in susceptibility-weighted imaging (SWI) exams in patients with sickle cell disease (SCD).

Materials And Methods: We conducted a retrospective study and qualitatively reviewed for hypointense arterial vessel contamination in SWI exams from 21 children with SCD. We developed a postprocessing framework using magnetic resonance angiography in combination with SWI to provide a more accurate quantification of NVVV. NVVV was calculated before and after removing arterial vessel contributions to determine the error from hypointense arterial vessels in quantifying NVVV.

Results: Hypointense arterial vessel contamination was observed in 86% SWI exams and was successfully corrected by the proposed method. The contributions of hypointense arterial vessels in the original SWI were significant and accounted for approximately 33% of the NVVV [uncorrected NVVV = 0.012 ± 0.005 versus corrected NVVV = 0.008 ± 0.003 (mean ± SD), < 0.01].

Conclusion: Hypointense arterial vessel contamination occurred in the majority of SWI exams and led to a sizeable overestimation of the visible venous volume. A prospective longitudinal study is needed to evaluate if quantitation of NVVV was improved and to assess the role of NVVV as a biomarker of SCD severity or stroke risk.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592388PMC
http://dx.doi.org/10.1155/2017/5369385DOI Listing

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