AI Article Synopsis
- Cembrane-type diterpenoids are natural products commonly found in soft corals, and the study focused on identifying anti-inflammatory compounds from a specific wild-type soft coral.
- Two new compounds, lobophyolide A and B, were discovered alongside five previously known cembranoids, with their structures confirmed through NMR and MS analyses.
- The newly isolated compounds showed significant anti-inflammatory effects by reducing IL-12 and NO production in LPS-activated dendritic cells, suggesting potential for therapeutic use.
Article Abstract
Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus . In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral , two new cembranoids, lobophyolide A () and B (), along with five known compounds (-), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound was found to possess the first identified -epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1- was evaluated. The results showed that compounds 1- not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666433 | PMC |
| http://dx.doi.org/10.3390/md15100327 | DOI Listing |
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