Standard Assays for the Study of Autophagy in the Ex Vivo Retina.

Cells

Departament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, 28040 Madrid, Spain.

Published: October 2017

AI Article Synopsis

  • - Autophagy is a process that breaks down and recycles parts of cells, playing an essential role in various bodily functions.
  • - In the eye, particularly the retina, autophagy is crucial for maintaining balance and health, making the retina a good model for studying brain functions and issues.
  • - The text discusses different techniques to study autophagy in the retina under both normal and disease conditions, highlighting its importance in understanding eye health and neurological processes.

Article Abstract

Autophagy is a catabolic pathway that mediates the degradation and recycling of intracellular components, and is a key player in a variety of physiological processes in cells and tissues. Recent studies of autophagy in the eye suggest that this pathway is fundamental for the preservation of retinal homeostasis. Given its accessible location outside the brain, the retina is an ideal organ in which to study the central nervous system and a wide range of neuronal processes, from development to neurodegeneration. Here we review several methods used to assess autophagy in the retina in both physiological and pathological conditions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755496PMC
http://dx.doi.org/10.3390/cells6040037DOI Listing

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